Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Warren, H.R.; Evangelou, E.; Cabrera, C.P.; Gao, H.; Ren, M.; Mifsud, B.; Ntalla, I.; Surendran, P.; Liu, C.; Cook, J.P.; Kraja, A.T.; Drenos, F.; Loh, M.; Verweij, N.; Marten, J.; Karaman, I.; Lepe, M.P.; O'Reilly, P.F.; Knight, J.; Snieder, H.; Kato, N.; He, J.; Tai, E.S.; Said, M.A.; Porteous, D.; Alver, M.; Poulter, N.; Farrall, M.; Gansevoort, R.T.; Padmanabhan, S.; Mägi, R.; Stanton, A.; Connell, J.; Bakker, S.J.; Metspalu, A.; Shields, D.C.; Thom, S.; Brown, M.; Sever, P.; Esko, T.; Hayward, C.; van der Harst, P.; Saleheen, D.; Chowdhury, R.; Chambers, J.C.; Chasman, D.I.; Chakravarti, A.; Newton-Cheh, C.; Lindgren, C.M.; Levy, D.; Kooner, J.S.; Keavney, B.; Tomaszewski, M.; Samani, N.J.; Howson, J.M.; Tobin, M.D.; Munroe, P.B.; Ehret, G.B.; Wain, L.V.

doi:10.1038/ng.3768

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Détails

Télécharger: 28135244_BIB_3DE32D5D8A36.pdf (1916.46 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée

ID Serval

serval:BIB_3DE32D5D8A36

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Périodique

Nature genetics

Auteur⸱e⸱s

Warren H.R., Evangelou E., Cabrera C.P., Gao H., Ren M., Mifsud B., Ntalla I., Surendran P., Liu C., Cook J.P., Kraja A.T., Drenos F., Loh M., Verweij N., Marten J., Karaman I., Lepe M.P., O'Reilly P.F., Knight J., Snieder H., Kato N., He J., Tai E.S., Said M.A., Porteous D., Alver M., Poulter N., Farrall M., Gansevoort R.T., Padmanabhan S., Mägi R., Stanton A., Connell J., Bakker S.J., Metspalu A., Shields D.C., Thom S., Brown M., Sever P., Esko T., Hayward C., van der Harst P., Saleheen D., Chowdhury R., Chambers J.C., Chasman D.I., Chakravarti A., Newton-Cheh C., Lindgren C.M., Levy D., Kooner J.S., Keavney B., Tomaszewski M., Samani N.J., Howson J.M., Tobin M.D., Munroe P.B., Ehret G.B., Wain L.V.

Collaborateur⸱rice⸱s

International Consortium of Blood Pressure (ICBP) 1000G Analyses, BIOS Consortium, Lifelines Cohort Study, Understanding Society Scientific group, CHD Exome+ Consortium, ExomeBP Consortium, T2D-GENES Consortium, GoT2DGenes Consortium, Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, UK Biobank CardioMetabolic Consortium BP working group

Contributeur⸱rice⸱s

Völker U., Vollenweider P., Wild S., Willemsen G., Wright A.F., Yao J., Thériault S., Conen D., John A., Sever P., Debette S., Mook-Kanamori D.O., Zeggini E., Spector T.D., van der Harst P., Palmer C.N., Vergnaud A.C., Loos R.J., Polasek O., Starr J.M., Girotto G., Hayward C., Kooner J.S., Lindgren C.M., Vitart V., Samani N.J., Tuomilehto J., Gyllensten U., Knekt P., Deary I.J., Ciullo M., Elosua R., Keavney B.D., Hicks A.A., Scott R.A., Gasparini P., Laan M., Liu Y., Watkins H., Hartman C.A., Salomaa V., Toniolo D., Perola M., Wilson J.F., Schmidt H., Zhao J.H., Lehtimäki T., van Duijn C.M., Gudnason V., Psaty B.M., Peters A., Rettig R., James A., Jukema J.W., Strachan D.P., Palmas W., Metspalu A., Ingelsson E., Boomsma D.I., Franco O.H., Bochud M., Newton-Cheh C., Munroe P.B., Elliott P., Chasman D.I., Chakravarti A., Knight J., Morris A.P., Levy D., Tobin M.D., Snieder H., Caulfield M.J., Ehret G.B., Barnes M.R., Tzoulaki I., Caulfield M.J., Elliott P.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Statut éditorial

Publié

Date de publication

04/2017

Peer-reviewed

Oui

Volume

Numéro

Pages

403-415

Langue

anglais

Notes

Publication types: Journal Article
Publication Status: ppublish

Résumé

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

URN

urn:nbn:ch:serval-BIB_3DE32D5D8A366

OAI-PMH

oai:serval.unil.ch:BIB_3DE32D5D8A36

DOI

10.1038/ng.3768

Pubmed

28135244

Web of science

000394917800014

Création de la notice

03/04/2017 18:12