Comparison of the effect of renin inhibition and angiotensin-converting enzyme inhibition in ovine heart failure

Détails

ID Serval
serval:BIB_3D6AEECAC04A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of the effect of renin inhibition and angiotensin-converting enzyme inhibition in ovine heart failure
Périodique
Journal of Cardiovascular Pharmacology
Auteur⸱e⸱s
Fitzpatrick  M. A., Rademaker  M. T., Charles  C. J., Yandle  T. G., Espiner  E. A., Ikram  H., Nussberger  J.
ISSN
0160-2446 (Print)
Statut éditorial
Publié
Date de publication
02/1992
Volume
19
Numéro
2
Pages
169-75
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
The acute hemodynamic and hormonal effects of incremental doses of a specific ovine renin inhibitor (RI: EMD 52 297) and captopril were compared in an ovine model of heart failure. Both RI and captopril inhibited the renin-angiotensin II (ANG II) system, although the decrease in plasma aldosterone (ALDO) was significant only during captopril infusion. Both agents exhibited strong vasodilator properties with similar decreases in mean arterial pressure (MAP, maximum decrease: RI = -20.5 +/- 2.2 mm Hg, p less than 0.001; captopril = -19.8 +/- 1.7 mm Hg, p less than 0.001) and left atrial pressure (LAP, maximum, decrease: RI = -6.8 +/- 1.5 mm Hg, p less than 0.01; captopril = -6.9 +/- 0.4 mm Hg, p less than 0.01) along with a slight increase in cardiac output (CO, maximum increase: RI = 0.54 +/- 0.11 L/min; captopril = 0.79 +/- 0.26 L/min). The slope of the response between MAP and LAP was similar in all animals, indicating that the agents have a similar effect on cardiac preload and afterload. The similar hemodynamic actions of RI and captopril in this model of congestive heart failure suggest that beneficial effects are due to inhibition of ANG II. Thus, orally active renin inhibitors may offer a useful therapeutic alternative when side effects preclude use of angiotensin-converting enzyme (ACE) inhibitors.
Mots-clé
Aldosterone/blood Angiotensin II/blood Angiotensin-Converting Enzyme Inhibitors/*pharmacology Animals Atrial Natriuretic Factor/blood Captopril/administration & dosage/pharmacology Catheterization Heart Failure, Congestive/*drug therapy/physiopathology Hemodynamic Processes/drug effects Male Oligopeptides/administration & dosage/*pharmacology Renin/*antagonists & inhibitors Sheep
Pubmed
Web of science
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 13:33
Données d'usage