Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism.

Détails

ID Serval
serval:BIB_3D334D5DAC1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism.
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur⸱e⸱s
Yialamas M.A., Dwyer A.A., Hanley E., Lee H., Pitteloud N., Hayes F.J.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
92
Numéro
11
Pages
4254-4259
Langue
anglais
Notes
Publication types: Journal Article
Résumé
CONTEXT: Evidence suggests that testosterone (T) influences insulin sensitivity in men. The mechanism of this effect is unclear but is thought to involve changes in body composition.
OBJECTIVE: The aim of this study was to determine whether acute sex steroid withdrawal decreases insulin sensitivity in young, healthy men with idiopathic hypogonadotropic hypogonadism (IHH).
DESIGN: This was a 2-wk prospective study.
SETTING: The study was conducted at a General Clinical Research Center.
PATIENTS: Twelve men with IHH (age 40.8 +/- 2.8 yr) were studied: 1) on hormone replacement with normal T levels and 2) 2 wk after discontinuing therapy.
MAIN OUTCOME MEASURES: Each evaluation comprised a 75-g oral glucose tolerance test with assessment of insulin sensitivity (fasting insulin levels, homeostatic model assessment for insulin resistance, and Matsuda insulin sensitivity index) and insulin secretion (corrected insulin response). Serum cortisol, leptin, adiponectin, free fatty acids, IL-6, C-reactive protein, and TNF-alpha levels were also measured.
RESULTS: Body mass index was unchanged (27.1 +/- 1.1 to 27.2 +/- 1.1 kg/m(2)). Serum T levels decreased from 529 +/- 65 to 28 +/- 8 ng/dl (P < 0.00005). Fasting insulin levels increased from 4.9 +/- 0.7 to 6.2 +/- 0.6 microU/ml (P = 0.005), homeostatic model assessment of insulin resistance increased from 1.07 +/- 0.2 to 1.4 +/- 1.01 (P < 0.005), and insulin sensitivity index decreased from 11.0 +/- 2.3 to 7.5 +/- 0.7 (P < 0.05). There was a trend for fasting glucose levels to increase, 86.7 +/- 1.3 to 90.8 +/- 1.7 mg/dl (P = 0.09). IL-6 levels increased from 1.2 +/- 0.2 to 2.4 +/- 0.5 pg/ml (P < 0.01), whereas TNF-alpha levels decreased from 1.0 +/- 0.1 to 0.6 +/- 0.1 pg/ml (P < 0.05). No other significant changes were observed.
CONCLUSIONS: 1) Acute sex steroid withdrawal reduces insulin sensitivity in young healthy IHH men. 2) The acuity of the hypogonadism and absence of changes in body mass index or leptin levels suggest that sex steroids modulate insulin sensitivity in the absence of apparent or detectable changes in body composition.
Mots-clé
Adipokines/metabolism, Adult, Aged, Body Composition/physiology, Body Mass Index, Cytokines/blood, Gonadal Steroid Hormones/adverse effects, Gonadotropins/deficiency, Humans, Hypogonadism/complications, Hypogonadism/physiopathology, Insulin Resistance/physiology, Male, Middle Aged, Substance Withdrawal Syndrome/physiopathology, Testosterone/blood, Testosterone/deficiency
Pubmed
Open Access
Oui
Création de la notice
03/12/2014 15:36
Dernière modification de la notice
20/08/2019 13:33
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