Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study.

Détails

ID Serval
serval:BIB_3D2A76B0919C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study.
Périodique
Journal of Hepatology
Auteur⸱e⸱s
Moldovan B., Mentha G., Majno P., Berney T., Morard I., Giostra E., Wildhaber B.E., Van Delden C., Morel P., Toso C.
ISSN
1600-0641 (Electronic)
ISSN-L
0168-8278
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
55
Numéro
6
Pages
1222-1226
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND & AIMS: Herpes simplex virus hepatitis is a rare, but severe disease, thus far only documented by case reports and short series. The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis.
METHODS: We assessed demographics and outcome of all listed patients, and further conducted a case-control study, matching each transplanted patient with 10 controls. Matching criteria included: transplant status, MELD score ±5, transplant date ±6 months, and age at transplant ±5 years. During the study period, 30 patients were listed for HSV hepatitis. Of the 30 listed patients, seven recovered spontaneously and five died, prior to transplantation. The remaining 10 children and eight adults were transplanted.
RESULTS: The chance of recovery was significantly higher in children than in adults (7/19 vs. 0/11, p=0.02). In children, survival was similar between HSV patients and the matched controls (5-year survival: 69% vs. 64%, p=0.89). Conversely, survival was poor in adult HSV (5-year survival: 38% vs. 65%, p=0.006), with 62% of them dying within the first 12 months. All three reported post-transplant deaths in children were independent from HSV. Among the seven adult post-transplant deaths, four were related to infection (bacterial, fungal, or viral).
CONCLUSIONS: Children listed for HSV hepatitis have a significantly better survival than adults both prior and after liver transplantation. While HSV fulminant hepatitis is an appropriate indication for liver transplantation in children, it should only be performed in selected adult patients in otherwise good condition.
Mots-clé
Adolescent, Adult, Age Factors, Case-Control Studies, Child, Child, Preschool, Female, Hepatitis, Viral, Human/surgery, Herpes Simplex/surgery, Humans, Infant, Infant, Newborn, Kaplan-Meier Estimate, Liver Transplantation, Male, Middle Aged, Registries, Treatment Outcome, Waiting Lists, Young Adult
Pubmed
Web of science
Création de la notice
21/02/2015 12:08
Dernière modification de la notice
20/08/2019 14:33
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