Correlation between dynamic susceptibility contrast perfusion MRI and methionine metabolism in brain gliomas: preliminary results.

Détails

ID Serval
serval:BIB_3D1C73F25C7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Correlation between dynamic susceptibility contrast perfusion MRI and methionine metabolism in brain gliomas: preliminary results.
Périodique
Journal of Magnetic Resonance Imaging
Auteur⸱e⸱s
Sadeghi N., Salmon I., Tang B.N., Denolin V., Levivier M., Wikler D., Rorive S., Balériaux D., Metens T., Goldman S.
ISSN
1053-1807 (Print)
ISSN-L
1053-1807
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
24
Numéro
5
Pages
989-994
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
PURPOSE: To evaluate in brain gliomas the relationship between tumor vascularity measured by MR-based maximum regional cerebral blood volume (rCBV) and tumor amino-acid metabolism based on maximum carbon-11 methionine (MET) uptake on positron emission tomography (PET).
MATERIALS AND METHODS: Eighteen patients with histologically proven primary brain gliomas were included in the study. In addition to conventional MR sequences, dynamic MR images, including a first-pass gadopentetate dimeglumine T2*-weighted echo-planar perfusion sequence and a PET study using MET, were acquired. Eleven patients had low-grade gliomas, and seven had high-grade gliomas. rCBV ratios and MET uptake ratios normalized to the contralateral white matter (WM) corresponding values were measured in each tumor. Both maximum rCBV ratios and maximum MET uptake ratios were correlated to histopathology. The maximum rCBV ratios were correlated to the maximum MET uptake ratios.
RESULTS: Both the maximum rCBV ratios and maximum MET uptake ratios of high-grade gliomas were significantly higher than those of low-grade gliomas (P<0.05). There was a significant positive correlation between maximum rCBV ratios and maximum MET uptake ratios (Spearman: r=0.89, P<0.00001).
CONCLUSION: The maximum rCBV ratio and maximum MET uptake ratio are significantly correlated in gliomas, reflecting a close link between amino acid uptake and vascularity in these tumors.
Mots-clé
Adult, Aged, Brain Neoplasms/blood supply, Brain Neoplasms/diagnosis, Cerebrovascular Circulation, Contrast Media, Female, Glioma/blood supply, Glioma/diagnosis, Humans, Magnetic Resonance Imaging/methods, Male, Methionine/analogs & derivatives, Methionine/diagnostic use, Middle Aged, Pilot Projects, Positron-Emission Tomography/methods, Radiopharmaceuticals/diagnostic use, Radiopharmaceuticals/pharmacokinetics, Reproducibility of Results, Sensitivity and Specificity, Statistics as Topic
Pubmed
Web of science
Création de la notice
20/01/2008 17:36
Dernière modification de la notice
20/08/2019 13:33
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