Sensitization after kidney transplantation.

Détails

ID Serval
serval:BIB_3D186AE1880B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Sensitization after kidney transplantation.
Périodique
Clinical Journal of the American Society of Nephrology
Auteur(s)
Akalin E., Pascual M.
ISSN
1555-905X[electronic]
Statut éditorial
Publié
Date de publication
2006
Volume
1
Numéro
3
Pages
433-440
Langue
anglais
Résumé
Kidney transplant recipients may develop de novo anti-HLA and non-HLA antibodies after transplantation. Although these antibodies may be donor-specific or non-donor-specific, their presence may increase the risk for acute and chronic rejection, thereby decreasing allograft survival. The introduction of more sensitive and specific methods to detect anti-HLA antibodies, such as Flow Specific Beads and FlowPRA, both before and after transplantation, will help to define immunologically high-risk kidney transplant recipients. Thus, posttransplantation monitoring of anti-HLA antibody production will allow the identification of kidney transplant recipients who might be at increased risk for late allograft failure. Moreover, knowledge of alloantibody status after transplantation may help to guide the appropriate use of immunomodulatory agents to downregulate anti-HLA antibody production.
Mots-clé
Antibody Formation, Graft Rejection/immunology, HLA Antigens/immunology, Humans, Kidney Transplantation/immunology, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 14:53
Dernière modification de la notice
20/08/2019 14:33
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