The relation between solid cell nests and C cells of the thyroid gland: an immunohistochemical and morphometric investigation.

Détails

ID Serval
serval:BIB_3D00065AA4FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The relation between solid cell nests and C cells of the thyroid gland: an immunohistochemical and morphometric investigation.
Périodique
Cell and Tissue Research
Auteur(s)
Janzer R.C., Weber E., Hedinger C.
ISSN
0302-766X[print], 0302-766X[linking]
Statut éditorial
Publié
Date de publication
1979
Volume
197
Numéro
2
Pages
295-312
Langue
anglais
Résumé
Thyroid tissue of 300 routine autopsies was processed in a standardized manner. So-called solid cell nests (SCN) were found in 21 patients (7%). These cases were investigated carefully by serial step sectioning. In order to explore the correlation of SCN to the C-cell system, the sections were stained by silver impregnation and the immunoperoxidase method. Morphometric analyses revealed a significant increase in the density of C cells in the proximity of the SCN. With progressive distance from the SCN, the C-cell density decreased and reached normal values. In 30% of the cases argyrophilic and calcitonin-positive cells were found lying within the SCN. Occasionally, mixed follicles could be discerned: These were lined on the one side by a multilayered squamous epithelium, on the other side by normal monolayered cubic follicular epithelium, and contained a peculiar granular material. In one case, SCN were associated with intrathyroid portions of the parathyroids and adult adipose tissue, in a second case with adipose tissue only. Most probably SCN are vestiges of the ultimobranchial body and should be interpreted as such, despite the fact that other authors have expressed different views. The lack of disturbances in the calcium metabolism of the patients and the absence of medullary carcinoma in their family histories led us to interpret locally confined C-cell hyperplasia not as reactive nor premalignant, but rather as normal.
Mots-clé
Adipose Tissue, Adult, Aged, Branchioma/pathology, Calcitonin/metabolism, Cell Count, Choristoma/pathology, Epithelium/anatomy & histology, Female, Histocytochemistry, Humans, Male, Middle Aged, Parathyroid Glands, Thyroid Gland/anatomy & histology, Thyroid Gland/metabolism, Thyroid Neoplasms/pathology
Pubmed
Création de la notice
21/10/2010 9:44
Dernière modification de la notice
20/08/2019 14:33
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