Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioral correlates

Détails

ID Serval
serval:BIB_3CE1D9A58789
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioral correlates
Périodique
Life Sciences
Auteur(s)
Brunello  N., Volterra  A., Di Giulio  A. M., Cuomo  V., Racagni  G.
ISSN
0024-3205 (Print)
Statut éditorial
Publié
Date de publication
04/1984
Volume
34
Numéro
17
Pages
1669-78
Notes
Comparative Study
Journal Article --- Old month value: Apr 23
Résumé
C57 BL/6J (C57) mice display a particular pattern of responses following morphine administration, such as a rapid development of tolerance to the pharmacological action of the opiate and an increase in locomotor activity after a single injection of the drug. We have measured met-enkephalin content and the responsiveness of different opiate receptors after repeated administration of morphine and naloxone. Prolonged morphine administration changes neither met-enkephalin levels, nor the density of the opiate receptors in mice brain. In contrast repeated administration of the opiate antagonist naloxone, produced a marked increase in the number of 3H- DHM and 3H- DADLE binding sites in striatum and brainstem without modifying met-enkephalin concentrations. Behavioral studies have indicated that the morphine-induced increase in locomotor activity is enhanced in naloxone pretreated mice, thus suggesting a possible correlation between the behavioral response to morphine in C57 mice and the higher number of opiate receptors in the striatum.
Mots-clé
Animals Brain/*metabolism Brain Stem/metabolism Cerebral Cortex/metabolism Corpus Striatum/metabolism Enkephalin, Methionine/metabolism Kinetics Locomotion/drug effects Male Mice Mice, Inbred C57BL Morphine/*pharmacology Naloxone/*pharmacology Radioligand Assay Receptors, Opioid/drug effects/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:37
Dernière modification de la notice
20/08/2019 14:33
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