Total hemoglobin mass--a new parameter to detect blood doping?

Détails

ID Serval
serval:BIB_3CD2FFDAC098
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Total hemoglobin mass--a new parameter to detect blood doping?
Périodique
Medicine and Science in Sports and Exercise
Auteur(s)
Prommer N., Sottas P.E., Schoch C., Schumacher Y.O., Schmidt W.
ISSN
1530-0315[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
40
Numéro
12
Pages
2112-2118
Langue
anglais
Résumé
PURPOSE: All kinds of blood manipulations aim to increase the total hemoglobin mass (tHb-mass). To establish tHb-mass as an effective screening parameter for detecting blood doping, the knowledge of its normal variation over time is necessary. The aim of the present study, therefore, was to determine the intraindividual variance of tHb-mass in elite athletes during a training year emphasizing off, training, and race seasons at sea level. METHODS: tHb-mass and hemoglobin concentration ([Hb]) were determined in 24 endurance athletes five times during a year and were compared with a control group (n = 6). An analysis of covariance was used to test the effects of training phases, age, gender, competition level, body mass, and training volume. Three error models, based on 1) a total percentage error of measurement, 2) the combination of a typical percentage error (TE) of analytical origin with an absolute SD of biological origin, and 3) between-subject and within-subject variance components as obtained by an analysis of variance, were tested. RESULTS: In addition to the expected influence of performance status, the main results were that the effects of training volume (P = 0.20) and training phases (P = 0.81) on tHb-mass were not significant. We found that within-subject variations mainly have an analytical origin (TE approximately 1.4%) and a very small SD (7.5 g) of biological origin. CONCLUSION: tHb-mass shows very low individual oscillations during a training year (<6%), and these oscillations are below the expected changes in tHb-mass due to Herythropoetin (EPO) application or blood infusion (approximately 10%). The high stability of tHb-mass over a period of 1 year suggests that it should be included in an athlete's biological passport and analyzed by recently developed probabilistic inference techniques that define subject-based reference ranges.
Mots-clé
Case-Control Studies, Doping in Sports, Erythropoietin, Recombinant/administration & dosage, Hemoglobins/analysis, Humans, Physical Endurance, Reference Values, Reproducibility of Results, Sports, Substance Abuse Detection/methods
Pubmed
Web of science
Création de la notice
03/10/2009 12:45
Dernière modification de la notice
20/08/2019 14:33
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