Remodelling and inflammation in preschoolers with severe recurrent wheeze and asthma outcome at school age.
Détails
ID Serval
serval:BIB_3CCFCF2AD060
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Remodelling and inflammation in preschoolers with severe recurrent wheeze and asthma outcome at school age.
Périodique
Clinical and experimental allergy
ISSN
1365-2222 (Electronic)
ISSN-L
0954-7894
Statut éditorial
Publié
Date de publication
07/2018
Peer-reviewed
Oui
Volume
48
Numéro
7
Pages
806-813
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The influence of airway remodelling and inflammation in preschoolers with severe recurrent wheeze on asthma outcomes is poorly understood.
To assess their association with asthma symptoms and lung function at school age.
Preschoolers (38.4 months) initially investigated with bronchial biopsies were re-assessed for asthma symptoms and lung function at school age.
Thirty-six of 49 preschoolers (73.5%) were assessed at 10.9 years. Twenty-six (72.2%) had persistent asthma. Submucosal eosinophil counts were higher in children with severe exacerbations at school age than in those without (16/0.1 mm <sup>2</sup> [11.2-30.4] vs 8/0.1 mm <sup>2</sup> [2.4-17.6], P = .02), and correlated with the number of severe exacerbations (P = .04, r = .35). Submucosal neutrophil counts correlated with FEV1/FVC (P < .01, r = .47) and FEF <sub>25-75%</sub> predicted (P = .02, r = .43). Airway smooth muscle (ASM) area correlated with FEV1/FVC (P < .01, r = .51). Vessel numbers negatively correlated with FEV1% predicted and FEV1/FVC (P = .03, r = -.42; P = .04, r = -.41; respectively) and FEF <sub>25-75%</sub> predicted (P = .02, r = -.46).
Eosinophilic inflammation in preschoolers with severe recurrent wheeze might be predictive of future severe exacerbations, neutrophilia might be associated with better lung function. Changes in ASM and vascularity might affect lung function at school age.
To assess their association with asthma symptoms and lung function at school age.
Preschoolers (38.4 months) initially investigated with bronchial biopsies were re-assessed for asthma symptoms and lung function at school age.
Thirty-six of 49 preschoolers (73.5%) were assessed at 10.9 years. Twenty-six (72.2%) had persistent asthma. Submucosal eosinophil counts were higher in children with severe exacerbations at school age than in those without (16/0.1 mm <sup>2</sup> [11.2-30.4] vs 8/0.1 mm <sup>2</sup> [2.4-17.6], P = .02), and correlated with the number of severe exacerbations (P = .04, r = .35). Submucosal neutrophil counts correlated with FEV1/FVC (P < .01, r = .47) and FEF <sub>25-75%</sub> predicted (P = .02, r = .43). Airway smooth muscle (ASM) area correlated with FEV1/FVC (P < .01, r = .51). Vessel numbers negatively correlated with FEV1% predicted and FEV1/FVC (P = .03, r = -.42; P = .04, r = -.41; respectively) and FEF <sub>25-75%</sub> predicted (P = .02, r = -.46).
Eosinophilic inflammation in preschoolers with severe recurrent wheeze might be predictive of future severe exacerbations, neutrophilia might be associated with better lung function. Changes in ASM and vascularity might affect lung function at school age.
Mots-clé
Age Factors, Airway Remodeling, Allergens/immunology, Asthma/complications, Asthma/diagnosis, Asthma/epidemiology, Asthma/etiology, Biomarkers, Child, Child, Preschool, Female, Humans, Immunoglobulin E/immunology, Infant, Inflammation/epidemiology, Inflammation/etiology, Leukocyte Count, Male, Patient Outcome Assessment, Recurrence, Respiratory Function Tests, Respiratory Sounds/etiology, Severity of Illness Index, Spirometry, Airway inflammation, Airway remodeling, Asthma outcome, Eosinophils, Lung function, Preschool wheezers, Severe asthma
Pubmed
Web of science
Site de l'éditeur
Open Access
Oui
Création de la notice
15/05/2020 17:27
Dernière modification de la notice
16/05/2020 6:26
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