Monoclonal AKR/J thymic leukemias contain multiple JH immunoglobulin gene rearrangements.

Détails

ID Serval
serval:BIB_3CCF4EFC3789
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Monoclonal AKR/J thymic leukemias contain multiple JH immunoglobulin gene rearrangements.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Herr W., Perlmutter A.P., Gilbert W.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
1983
Volume
80
Numéro
24
Pages
7433-7436
Langue
anglais
Résumé
We have examined the patterns of heavy-chain immunoglobulin gene rearrangement and provirus integration in seven murine leukemia virus-induced thymic leukemias from AKR/J mice. In five of the seven tumors examined, there were between two and five rearrangements of the heavy-chain immunoglobulin J (JH) segment. Except for one case, the rearranged JH segments are present in less than one copy per cell, indicating that these tumors contain subpopulations of thymocytes with differing JH rearrangements. Nevertheless, each tumor is probably of monoclonal origin because the cells in a given tumor contain a common set of randomly integrated murine leukemia proviruses. Our results indicate that the JH segments rearranged within a few cell divisions after tumor cell proliferation began and may, therefore, identify a specific stage in T-cell differentiation when tumorigenesis occurs.
Mots-clé
Animals, Base Sequence, DNA Restriction Enzymes, Genes, Immunoglobulin Heavy Chains/genetics, Immunoglobulin J-Chains/genetics, Leukemia, Experimental/immunology, Mice, Mice, Inbred AKR, Nucleic Acid Hybridization, Thymoma/immunology, Thymus Neoplasms/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:36
Dernière modification de la notice
20/08/2019 13:33
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