Reproduction, fat metabolism, and life span: what is the connection?

Détails

Ressource 1Télécharger: BIB_3CB17DB1C9A2.P001.pdf (1786.86 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_3CB17DB1C9A2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Reproduction, fat metabolism, and life span: what is the connection?
Périodique
Cell Metabolism
Auteur⸱e⸱s
Hansen M., Flatt T., Aguilaniu H.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
10-19
Langue
anglais
Résumé
Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies in several species provide evidence that reproduction, fat metabolism, and longevity are directly coupled. For instance, germline removal in the nematode Caenorhabditis elegans promotes longevity in part by modulating lipid metabolism through effects on fatty acid desaturation, lipolysis, and autophagy. Here, we review these recent studies and discuss the mechanisms by which reproduction modulates fat metabolism and life span. Elucidating the relationship between these processes could contribute to our understanding of age-related diseases including metabolic disorders.
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2013 11:13
Dernière modification de la notice
20/08/2019 13:32
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