MICA exon 5 microsatellite typing by DNA heteroduplex analysis: a new polymorphism in the transmembrane region

Détails

ID Serval
serval:BIB_3C6DD67F8CBB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
MICA exon 5 microsatellite typing by DNA heteroduplex analysis: a new polymorphism in the transmembrane region
Périodique
Tissue Antigens
Auteur(s)
Vitiani  L. R., Potolicchio  I., D'Amato  M., Baricordi  O. R., Sorrentino  R.
ISSN
0001-2815 (Print)
Statut éditorial
Publié
Date de publication
03/1998
Volume
51
Numéro
3
Pages
309-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
MICA (MHC class I chain-related gene A) is localized 47 kb upstream from HLA-B on the short arm of chromosome 6. It has been postulated that MICA protein folds similarly to the class I chain and may have the capacity to bind short ligands. Short tandem repeats (STR) within the transmembrane (TM) region of this gene have been described and five alleles consisting of 4 to 9 GCT codons, each encoding an alanine residue have been defined. We have applied DNA heteroduplex analysis to type MICA trinucleotide repeats in order to develop a simple and reliable method for their identification. This approach allowed the characterization of all MICA alleles. Moreover, a new polymorphism within the TM region was identified.
Mots-clé
Cell Line *Dna *Exons Histocompatibility Antigens Class I/*genetics Humans *Microsatellite Repeats *Nucleic Acid Heteroduplexes *Polymorphism, Genetic
Pubmed
Web of science
Création de la notice
25/01/2008 16:16
Dernière modification de la notice
20/08/2019 14:32
Données d'usage