Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal.
Détails
ID Serval
serval:BIB_3C539E138B45
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal.
Périodique
Cornea
ISSN
1536-4798 (Electronic)
ISSN-L
0277-3740
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
36
Numéro
3
Pages
377-378
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To report a case with refractory tamoxifen-induced keratopathy despite drug withdrawal.
Case report.
A 50-year-old woman, diagnosed with bilateral breast cancer underwent mastectomy in 2005. She was treated with tamoxifen citrate from 2005 to 2012. According to her medical history, no corneal abnormalities had been documented during past ophthalmological examinations except low myopia, before initiation of tamoxifen treatment. In 2009, 4 years after start of treatment, she was diagnosed with subepithelium deposits compatible with drug-induced keratopathy. The patient was examined again in 2016, 4 years after withdrawal of the drug with persistent tamoxifen-induced keratopathy.
Contrary to current literature, it seems that tamoxifen-induced corneal abnormalities may persist for years after drug withdrawal.
Case report.
A 50-year-old woman, diagnosed with bilateral breast cancer underwent mastectomy in 2005. She was treated with tamoxifen citrate from 2005 to 2012. According to her medical history, no corneal abnormalities had been documented during past ophthalmological examinations except low myopia, before initiation of tamoxifen treatment. In 2009, 4 years after start of treatment, she was diagnosed with subepithelium deposits compatible with drug-induced keratopathy. The patient was examined again in 2016, 4 years after withdrawal of the drug with persistent tamoxifen-induced keratopathy.
Contrary to current literature, it seems that tamoxifen-induced corneal abnormalities may persist for years after drug withdrawal.
Mots-clé
Breast Neoplasms/drug therapy, Breast Neoplasms/surgery, Chemotherapy, Adjuvant, Corneal Diseases/chemically induced, Corneal Diseases/diagnosis, Epithelium, Corneal/drug effects, Estrogen Antagonists/adverse effects, Female, Humans, Mastectomy, Middle Aged, Slit Lamp, Substance Withdrawal Syndrome, Tamoxifen/adverse effects, Tomography, Optical Coherence, Visual Acuity/drug effects
Pubmed
Web of science
Création de la notice
19/01/2018 15:24
Dernière modification de la notice
20/08/2019 14:32
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