Le traitement du glaucome a pression normale avec un antagoniste des recepteurs S2 de la serotonine, le naftidrofuryl (praxilen). [Treatment of normal pressure glaucoma with a serotonin S2 receptor antagonist, naftidrofuryl (praxilen)]
Détails
ID Serval
serval:BIB_3B68615ADDFF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Le traitement du glaucome a pression normale avec un antagoniste des recepteurs S2 de la serotonine, le naftidrofuryl (praxilen). [Treatment of normal pressure glaucoma with a serotonin S2 receptor antagonist, naftidrofuryl (praxilen)]
Périodique
Klinische Monatsblatter fur Augenheilkunde
ISSN
0023-2165 (Print)
Statut éditorial
Publié
Date de publication
05/1991
Volume
198
Numéro
5
Pages
332-4
Notes
Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article --- Old month value: May
Controlled Clinical Trial
English Abstract
Journal Article --- Old month value: May
Résumé
35 normal tension glaucoma patients were followed during 8 to 11 month. 12 patients received 2 x 200 mg/day Naftidrofuryl, a serotonine S2 receptor antagonist. As controles, another 23 patients were followed without treatment. The treated group, compared with the 23 non treated patients showed a significant increase in visual acuity (p = 0.001), a significant increase of the MS (p = 0.03), and a non significant decrease of the MD and CLV on the Octopus visual field (p, NS). The physiology and physiopathology of serotonine and S2 receptor antagonist are discussed.
Mots-clé
Aged
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Glaucoma/*drug therapy
Humans
Intraocular Pressure/*drug effects
Male
Nafronyl/*administration & dosage
Ophthalmic Solutions
Pilot Projects
*Serotonin Antagonists
Visual Acuity/drug effects
Visual Fields/drug effects
Pubmed
Web of science
Création de la notice
28/01/2008 13:49
Dernière modification de la notice
20/08/2019 14:31