Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma.
Détails
ID Serval
serval:BIB_3A8AFE57D6C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma.
Périodique
Blood
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
120
Numéro
19
Pages
3997-4005
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Peripheral T-cell lymphoma (PTCL) is a rare, heterogeneous type of non-Hodgkin lymphoma (NHL) that, in general, is associated with a poor clinical outcome. Therefore, a current major challenge is the discovery of new prognostic tools for this disease. In the present study, a cohort of 122 patients with PTCL was collected from a multicentric T-cell lymphoma consortium (TENOMIC). We analyzed the expression of 80 small nucleolar RNAs (snoRNAs) using high-throughput quantitative PCR. We demonstrate that snoRNA expression analysis may be useful in both the diagnosis of some subtypes of PTCL and the prognostication of both PTCL-not otherwise specified (PTCL-NOS; n = 26) and angio-immunoblastic T-cell lymphoma (AITL; n = 46) patients treated with chemotherapy. Like miRNAs, snoRNAs are globally down-regulated in tumor cells compared with their normal counterparts. In the present study, the snoRNA signature was robust enough to differentiate anaplastic large cell lymphoma (n = 32) from other PTCLs. For PTCL-NOS and AITL, we obtained 2 distinct prognostic signatures with a reduced set of 3 genes. Of particular interest was the prognostic value of HBII-239 snoRNA, which was significantly over-expressed in cases of AITL and PTCL-NOS that had favorable outcomes. Our results suggest that snoRNA expression profiles may have a diagnostic and prognostic significance for PTCL, offering new tools for patient care and follow-up.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/11/2012 11:39
Dernière modification de la notice
20/08/2019 14:30