Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis.

Détails

ID Serval
serval:BIB_3A89BE36D4EF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Compte-rendu: analyse d'une oeuvre publiée.
Collection
Publications
Titre
Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis.
Périodique
Journal of orthopaedic research
Auteur(s)
Geurts J. (co-premier), Patel A. (co-premier), Hirschmann M.T., Pagenstert G.I., Müller-Gerbl M., Valderrabano V., Hügle T.
ISSN
1554-527X (Electronic)
ISSN-L
0736-0266
Statut éditorial
Publié
Date de publication
02/2016
Peer-reviewed
Oui
Volume
34
Numéro
2
Pages
262-269
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Subchondral osteosclerosis, characterized by an increase of hypomineralized bone material, is a pathological hallmark of osteoarthritis. The cellular components in the subchondral marrow compartment that participate in this aberrant bone remodeling process remain to be elucidated. This study assessed the presence of marrow inflammatory cells and their relative abundance between nonsclerotic and sclerotic tissues in knee osteoarthritis. Bone samples from osteoarthritic knee tibial plateaus were stratified for histological analyses using computed tomography osteoabsorptiometry. Immunohistological analysis revealed the presence of CD20 (B-lymphocyte) and CD68 (macrophage), but not CD3 (T-lymphocyte) immunoreactive mononuclear cells in subchondral marrow tissues and their relative abundance was significantly increased in sclerotic compared with nonsclerotic bone samples. Multinucleated osteoclasts that stained positive for CD68 and tartrate-resistant acid phosphatase, predominantly associated with CD34-positive blood vessels and their abundance was strongly increased in sclerotic samples. Bone-specific alkaline phosphatase activity in outgrowth osteoblasts was induced by conditioned medium from nonsclerotic, but not sclerotic, bone pieces. These results suggest that an interaction between bone-resident cells and marrow inflammatory cells might play a role in aberrant bone remodeling leading to subchondral osteosclerosis. Elevated osteoclast activity in sclerotic bone suggests that bone formation and resorption activities are increased, yet uncoupled, in human knee osteoarthritis.
Mots-clé
Aged, Aged, 80 and over, Bone Marrow/immunology, Bone Marrow/pathology, Culture Media, Conditioned, Female, Humans, Male, Osteoarthritis, Knee/complications, Osteoarthritis, Knee/pathology, Osteoblasts/enzymology, Osteoclasts, Osteosclerosis/immunology, Osteosclerosis/pathology, Retrospective Studies, macrophages, osteoarthritis, osteoclast, osteosclerosis, subchondral bone
Pubmed
Web of science
Création de la notice
27/07/2020 18:50
Dernière modification de la notice
28/07/2020 6:26
Données d'usage