Lupus erythemateux dissemine sans anticorps antinucleaires et sans autres autoanticorps. [Disseminated lupus erythematosus without antinuclear antibodies or other autoantibodies]

Détails

ID Serval
serval:BIB_3A8507205710
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Lupus erythemateux dissemine sans anticorps antinucleaires et sans autres autoanticorps. [Disseminated lupus erythematosus without antinuclear antibodies or other autoantibodies]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Duc  J., Perroulaz  G., Golaz  J., Campiche  M., Pecoud  A.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
02/1987
Volume
117
Numéro
6
Pages
205-8
Notes
Case Reports
English Abstract
Journal Article --- Old month value: Feb 7
Résumé
Antinuclear antibodies (ANA) are found in the majority of patients with systemic lupus erythematosus (SLE). We report here the only documented case, out of a series of 38 patients, in which SLE was diagnosed in spite of the fact that we failed to demonstrate any type of autoantibodies. A 25-year-old black woman presented with 6 of the 11 criteria of the American Rheumatism Association for classification of SLE, between August 1984 and April 1985, i.e. malar rash, photosensitivity, arthritis, pleurisy and pericarditis, renal insufficiency and nephrotic syndrome, anemia and leukopenia. Renal biopsy revealed mesangial glomerulonephritis, tubulonephritis and many tubuloreticular inclusions in the capillary endothelium highly suggestive of SLE. Four ANA determinations were performed during the 8 months of observation which were all negative, as were all other antibodies (anti-nDNA, -Sm, -RPN, -Ro, -La). The outcome was very favourable under prednisone and cyclophosphamide. In the rare cases of ANA negative SLE (5-10%) photosensitive dermatitis is the prominent feature and renal or central nervous system involvement is less frequent. Those patients usually have other types of autoantibodies (especially anticytoplasmic) which was not the case in our patient. This indicates that the absence of autoantibodies does not rule out SLE.
Mots-clé
Adult Antibodies, Antinuclear/*analysis Autoantibodies/*analysis Cyclophosphamide/administration & dosage Drug Therapy, Combination Female Humans Lupus Erythematosus, Systemic/*diagnosis/drug therapy/immunology Prednisone/administration & dosage
Pubmed
Web of science
Création de la notice
28/01/2008 12:58
Dernière modification de la notice
20/08/2019 14:30
Données d'usage