Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role.

Détails

ID Serval
serval:BIB_3A5D4BA9B6D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role.
Périodique
Histopathology
Auteur(s)
Rahier J., Sempoux C., Fournet J.C., Poggi F., Brunelle F., Nihoul-Fekete C., Saudubray J.M., Jaubert F.
ISSN
0309-0167 (Print)
ISSN-L
0309-0167
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
32
Numéro
1
Pages
15-19
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
AIMS: To determine whether the presence of abnormal B-cell nuclei predicts the existence of a focal or of a diffuse form of persistent neonatal and infantile hyperinsulinaemic hypoglycaemia in a series of 20 infants.
METHODS AND RESULTS: Intra-operative frozen sections were performed on small specimens from the pancreatic head, isthmus and tail. In 13 cases, abnormal B-cell nuclei were identified, but even a near-total pancreatectomy was insufficient to cure some of these patients, in whom no focal lesion was detected. On the other hand, abnormal insular B-cell nuclei were not found in seven cases; based on the results of selective venous catheterization, a limited resection was performed, sufficient to cure each patient, and a focal adenomatous hyperplasia was found in each resected specimen.
CONCLUSIONS: Intra-operative examination of small pancreatic specimens taken from the different parts of the gland allows one to determine the type of lesion (focal or diffuse) in neonatal onset hyperinsulinaemic hypoglycaemia, and to decide on the most appropriate surgical treatment.
Mots-clé
Cell Nucleolus/pathology, Cell Nucleus/pathology, Chromatin/pathology, Diagnosis, Differential, Frozen Sections, Histocytochemistry, Humans, Hyperinsulinism/congenital, Hyperinsulinism/pathology, Hypoglycemia/congenital, Hypoglycemia/pathology, Infant, Islets of Langerhans/cytology, Islets of Langerhans/pathology, Microtomy, Pancreas/cytology, Pancreas/pathology, Pancreatectomy, Paraffin Embedding, Prognosis
Pubmed
Web of science
Création de la notice
20/10/2016 17:38
Dernière modification de la notice
20/08/2019 14:30
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