Prognostic Factors in Syphilitic Uveitis.

Détails

ID Serval
serval:BIB_39F58142FC21
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prognostic Factors in Syphilitic Uveitis.
Périodique
Ophthalmology
Auteur⸱e⸱s
Hoogewoud F., Frumholtz L., Loubet P., Charlier C., Blanche P., Lebeaux D., Benhaddou N., Sedira N., Coutte L., Vanhaecke C., Launay O., Le Jeunne C., Héron E., Monnet D., Lortholary O., Sahel J.A., Dupin N., Brézin A., Errera M.H., Salah S., Groh M.
ISSN
1549-4713 (Electronic)
ISSN-L
0161-6420
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
124
Numéro
12
Pages
1808-1816
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To identify predictors of treatment success in syphilitic uveitis (SU).
Retrospective multicentric analysis of patients treated for SU.
A total of 95 eyes (66 patients, mean [standard deviation] aged 49 [12.5] years, 31 [47%] of whom were human immunodeficiency virus [HIV]+) were analyzed.
Activity of SU was assessed at 1 week and 1 month after treatment onset, and at last follow-up. Improvement was defined by a ≥2-step decrease of both anterior chamber and vitreous haze inflammation levels, and by the size reduction in chorioretinal lesions.
Recovery was defined as the resolution of inflammation in all anatomic structures at 1 month.
Panuveitis and posterior uveitis were the most frequent findings. Inflammatory parameters were higher in HIV+ patients. Recovery was reported in 65% and 85% of eyes at 1 month and at last follow-up, respectively. In multivariate analysis, after adjusting for initial best-corrected visual acuity and the antimicrobial treatment regimen, clinical improvement at 1 week (corrected risk ratios [cRR], 3.5 [2.3-3.8]; P = 0.001) was predictive of recovery at 1 month, whereas the use of periocular dexamethasone injections (cRR, 0.05 [0.02-0.6]; P = 0.01) and methylprednisolone pulses negatively affected the outcomes of eyes.
Early improvement is the strongest predictor of ophthalmological recovery in SU.
Mots-clé
Adult, Anti-Bacterial Agents/therapeutic use, Azithromycin/therapeutic use, Doxycycline/therapeutic use, Eye Infections, Bacterial/diagnosis, Eye Infections, Bacterial/drug therapy, Eye Infections, Bacterial/microbiology, Female, Fluorescent Treponemal Antibody-Absorption Test, Follow-Up Studies, HIV Seropositivity, Humans, Male, Middle Aged, Penicillin G Benzathine/therapeutic use, Polymerase Chain Reaction, Prognosis, Retrospective Studies, Sulfadiazine/therapeutic use, Syphilis/diagnosis, Syphilis/drug therapy, Syphilis/microbiology, Syphilis Serodiagnosis, Uveitis/diagnosis, Uveitis/drug therapy, Uveitis/microbiology, Visual Acuity/physiology
Pubmed
Web of science
Création de la notice
08/03/2022 10:36
Dernière modification de la notice
06/04/2022 5:42
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