Determination of the efficiency of commercially available dose calibrators for beta-emitters

Détails

ID Serval
serval:BIB_39EC9E23888A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Determination of the efficiency of commercially available dose calibrators for beta-emitters
Périodique
Journal of nuclear medicine technology
Auteur(s)
Valley J.F., Bulling S., Leresche M., Wastiel C.
ISSN
0091-4916
Statut éditorial
Publié
Date de publication
2003
Volume
31
Numéro
1
Pages
27-32
Résumé
The goals of this investigation are to determine whether commercially available dose calibrators can be used to measure the activity of beta-emitting radionuclides used in pain palliation and to establish whether manufacturer-supplied calibration factors are appropriate for this purpose. METHODS: Six types of commercially available dose calibrators were studied. Dose calibrator response was controlled for 5 gamma-emitters used for calibration or typically encountered in routine use. For the 4 most commonly used beta-emitters ((32)P, (90)Sr, (90)Y, and (169)Er) dose calibrator efficiency was determined in the syringe geometry used for clinical applications. Efficiency of the calibrators was also measured for (153)Sm and (186)Re, 2 beta-emitters with significant gamma-contributions. Source activities were traceable to national standards. RESULTS: All calibrators measured gamma-emitters with a precision of +/-10%, in compliance with Swiss regulatory requirements. For beta-emitters, dose calibrator intrinsic efficiency depends strongly on the maximal energy of the beta-spectrum and is notably low for (169)Er. Manufacturer-supplied calibration factors give accurate results for beta-emitters with maximal beta-energy in the middle-energy range (1 MeV) but are not appropriate for use with low-energy ((169)Er) or high-energy ((90)Y) beta-emitters. beta-emitters with significant gamma-contributions behave like gamma-emitters. CONCLUSION: Commercially available dose calibrators have an intrinsic efficiency that is sufficient for the measurement of beta-emitters, including beta-emitters with a low maximum beta-energy. Manufacturer-supplied calibration factors are reliable for gamma-emitters and beta-emitters in the middle-energy range. For low- and high-energy beta-emitters, the use of manufacturer-supplied calibration factors introduces significant measurement inaccuracy.
Pubmed
Web of science
Création de la notice
28/04/2008 12:09
Dernière modification de la notice
20/08/2019 14:29
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