Posterior sub-Tenon's steroid injections for the treatment of posterior ocular inflammation: indications, efficacy and side effects

Détails

ID Serval
serval:BIB_398E1D7DBAC5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Posterior sub-Tenon's steroid injections for the treatment of posterior ocular inflammation: indications, efficacy and side effects
Périodique
Graefe's Archive for Clinical and Experimental Ophthalmology
Auteur⸱e⸱s
Lafranco Dafflon  M., Tran  V. T., Guex-Crosier  Y., Herbort  C. P.
ISSN
0721-832X (Print)
Statut éditorial
Publié
Date de publication
04/1999
Volume
237
Numéro
4
Pages
289-95
Notes
Comparative Study
Journal Article --- Old month value: Apr
Résumé
PURPOSE: Posterior sub-Tenon's steroid injections (PSTSI) are a standard drug delivery method used for the treatment of chronic uveitis of the posterior segment. The aim of this study was to analyse the indications, efficacy and complications of PSTSI in the treatment of chronic uveitis. METHODS: During the period 1990-1994, 53 (9.5%) of 558 patients (58 eyes) followed up in the uveitis clinic received a total of 162 PSTSI of triamcinolone acetonide 40 mg in the superior quadrants. Indications for treatment were vision inferior or equal to 0.7 and/or intolerable visual disturbance. Only patients in whom PSTSI were the only treatment parameter changed were analysed. Among the main parameters analysed were visual acuity, aqueous laser flare photometry, intraocular pressure (IOP) and complications. RESULTS: Anatomical location of uveitis was as follows: anterior HLA-B27-related uveitis with CME (1 patient/1 eye), intermediate uveitis (28/32), posterior uveitis (10/10) and panuveitis (14/15). Mean duration of follow-up was 448+/-57 days. Visual acuity improved significantly from 0.40+/-0.03 to 0.79+/-0.07, with 59.4% of eyes having a gain of 2-5 Snellen lines and 18.7% a gain of >5 lines. Mean aqueous flare photometry decreased significantly from 29.6+/-3.5 to 13.6+/-2.2 photons/ms. Mean IOP increased significantly from 13.6+/-0.5 to 18.5+/-0.8 mm Hg with a rise of pressure >8 mm Hg in 23 cases (36%), transient in 16 cases, but chronic in 6 cases, needing filtering surgery. Partial superior ptosis was seen in two cases and cataract progressed in seven cases. CONCLUSION: PSTSI are very effective in restoring visual acuity in chronic uveitis of the posterior segment, without systemic complications, but at the expense of intraocular hypertension, a complication that was found more frequently than expected.
Mots-clé
Adolescent Adult Aged Child Connective Tissue/drug effects Fascia/drug effects Female Follow-Up Studies Glucocorticoids/administration & dosage/*therapeutic use Humans Injections Intraocular Pressure Male Middle Aged Retrospective Studies Treatment Outcome Triamcinolone Acetonide/administration & dosage/*therapeutic use Uveitis, Posterior/*drug therapy Visual Acuity
Pubmed
Création de la notice
28/01/2008 12:45
Dernière modification de la notice
20/08/2019 13:29
Données d'usage