The METeoric rise of MET in lung cancer.

Détails

ID Serval
serval:BIB_392CF01A9189
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The METeoric rise of MET in lung cancer.
Périodique
Cancer
Auteur⸱e⸱s
Friedlaender A., Drilon A., Banna G.L., Peters S., Addeo A.
ISSN
1097-0142 (Electronic)
ISSN-L
0008-543X
Statut éditorial
Publié
Date de publication
15/11/2020
Peer-reviewed
Oui
Volume
126
Numéro
22
Pages
4826-4837
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non-small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation encompasses a heterogeneous array of alterations leading to the prolonged activation of the cellular MET (c-MET or MET) receptor and downstream proliferation pathways. It can arise through several mechanisms, including gene amplification, overexpression of the receptor and/or its ligand hepatocyte growth factor, and the acquisition of activating mutations. MET mutations are found in approximately 3% to 5% of patients with NSCLC, mainly adenocarcinoma, and are overrepresented in the sarcomatoid subtype. De novo MET amplifications are found in 1% to 5% of NSCLC cases, also predominantly in adenocarcinoma. In the current review, the authors discussed the biology of MET, how to diagnose clinically relevant alterations, and the rising clinical importance of these alterations in light of the emergence of multiple targeted therapies, both within the context of MET as a driver of resistance and in its own right.
Mots-clé
MET, molecular oncology, non-small cell lung cancer (NSCLC), precision medicine, targeted therapy
Pubmed
Web of science
Création de la notice
14/09/2020 8:52
Dernière modification de la notice
23/11/2020 6:24
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