The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism.

Détails

ID Serval
serval:BIB_39100A74EFAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism.
Périodique
PLoS pathogens
Auteur(s)
Reverte M., Eren R.O., Jha B., Desponds C., Snäkä T., Prevel F., Isorce N., Lye L.F., Owens K.L., Gazos Lopes U., Beverley S.M., Fasel N.
ISSN
1553-7374 (Electronic)
ISSN-L
1553-7366
Statut éditorial
Publié
Date de publication
03/2021
Peer-reviewed
Oui
Editeur scientifique
Stäger Simona
Volume
17
Numéro
3
Pages
e1009422
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The oxidative burst generated by the host immune system can restrict intracellular parasite entry and growth. While this burst leads to the induction of antioxidative enzymes, the molecular mechanisms and the consequences of this counter-response on the life of intracellular human parasites are largely unknown. The transcription factor NF-E2-related factor (NRF2) could be a key mediator of antioxidant signaling during infection due to the entry of parasites. Here, we showed that NRF2 was strongly upregulated in infection with the human Leishmania protozoan parasites, its activation was dependent on a NADPH oxidase 2 (NOX2) and SRC family of protein tyrosine kinases (SFKs) signaling pathway and it reprogrammed host cell metabolism. In inflammatory leishmaniasis caused by a viral endosymbiont inducing TNF-α in chronic leishmaniasis, NRF2 activation promoted parasite persistence but limited TNF-α production and tissue destruction. These data provided evidence of the dual role of NRF2 in protecting both the invading pathogen from reactive oxygen species and the host from an excess of the TNF-α destructive pro-inflammatory cytokine.
Mots-clé
Immunology, Genetics, Molecular Biology, Microbiology, Parasitology, Virology
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse
Fonds national suisse / 310030_173180
Création de la notice
27/03/2021 18:48
Dernière modification de la notice
01/05/2021 6:32
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