Tumor defense by murine cytotoxic T cells specific for peptide bound to nonclassical MHC class I
Détails
ID Serval
serval:BIB_3906FB0FB78D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Tumor defense by murine cytotoxic T cells specific for peptide bound to nonclassical MHC class I
Périodique
Cancer Research
ISSN
0008-5472 (Print)
Statut éditorial
Publié
Date de publication
10/1998
Volume
58
Numéro
20
Pages
4682-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct 15
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct 15
Résumé
Cytotoxic T Cells (CTLs) can exhibit considerable antitumor activity. Thus far, the characterized tumor peptide antigens recognized by CTLs are all presented by classical MHC class Ia molecules [human lymphocyte antigen A (HLA-A), HLA-B, and HLA-C in humans and H-2K, H-2D, and H-2L in mice]. Here we show that CTLs recognized peptides presented by nonclassical MHC class Ib molecule Qa-1b expressed by tumor cells. These CTLs conferred in vivo protection by delaying the growth of Qa-1b-expressing B78H1 melanoma cells pulsed with Qa-1b-binding peptides Cw4L or B35L and injected s.c. in C57BL/6 mice. A hierarchy of the peptides was found with regard to their ability to trigger CTLs; Cw4L stimulated a strong CTL response. The closely related and cross-reactive peptide B35L induced a weaker CTL response but was still efficient in sensitizing the target cells. Finally, Qa-1b-expressing melanoma cells without exogenous peptides were not immunogenic but possibly expressed endogenous cross-reactive antigenic peptides. The data are compatible with earlier findings that CTL activation requires relatively strong peptide antigens, whereas subsequent effector functions are also mediated by weak peptide analogues. In conclusion, CTLs mediated tumor immunity through the recognition of peptides presented by nonclassical MHC class Ib molecules. The identification of similar CTLs in humans may facilitate the vaccination of cancer patients because MHC class Ib/peptide complexes are much less polymorphic than MHC class Ia/peptide complexes.
Mots-clé
Animals
CD8-Positive T-Lymphocytes/immunology
Cross Reactions
Histocompatibility Antigens Class I/*physiology
Killer Cells, Natural/immunology
Melanoma, Experimental/*immunology
Mice
Mice, Inbred C57BL
T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:32
Dernière modification de la notice
20/08/2019 14:28