Effects of pumaprazole (BY841), a novel reversible proton pump antagonist, and of omeprazole, on intragastric acidity before and after cure of Helicobacter pylori infection
Détails
ID Serval
serval:BIB_38F4DB23E5F5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of pumaprazole (BY841), a novel reversible proton pump antagonist, and of omeprazole, on intragastric acidity before and after cure of Helicobacter pylori infection
Périodique
Alimentary Pharmacology and Therapeutics
ISSN
0269-2813 (Print)
Statut éditorial
Publié
Date de publication
01/1999
Volume
13
Numéro
1
Pages
27-34
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Jan
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
BACKGROUND: Omeprazole produces a higher intragastric pH in the presence of Helicobacter pylori infection than after cure. AIM: To investigate whether this effect also occurs with pumaprazole (BY841), a reversible proton pump antagonist which, in contrast to omeprazole, does not require activation in the acid compartment of the parietal cell. METHODS: In a randomized, crossover, double-blind study, 24-h intragastric pH was measured in 13 H. pylori-positive subjects before and after a 1-week course of omeprazole (20 mg o.d.) or of pumaprazole (100 mg b.d.). The studies were repeated after the infection was cured. RESULTS: In the absence of drug administration, the median 24-h pH values before cure (median 2.0, 90% CI: 1.2-3.2) did not differ from those after cure (median 1.5, 90% CI: 1.3-2.2; P = 0.115). The 24-h pH values were higher before cure of the infection than after during both pumaprazole (6.0, 4.8-6.7 vs. 4.3, 2.6-5.7; P = 0.002) and omeprazole (5.8, 4.0-6.2 vs. 3.6, 2.8-5; P = 0.004). Both before and after cure, there were no significant differences between the two drugs with respect to acid inhibition over the 24-h period. The median decrease in acid inhibition after cure of the infection (calculated as the difference in H+ activity in mmol/L) during pumaprazole (median 0.05, 90% CI: 6 x 10-4- 2.3) was no different from that during omeprazole (median 0.2, 90% CI: 3 x 10-3-1.5; P = 0.6). CONCLUSIONS: Both before and after cure of H. pylori infection, pumaprazole raised the intragastric pH over a 24-h period to a similar degree as omeprazole. H. pylori infection similarly augments the pH-increasing effect of both drugs. This effect is related to H. pylori infection and not to an increased activation of acid inhibitory agents in the parietal cell compartment.
Mots-clé
Adult
Antacids/*pharmacology
Anti-Ulcer Agents/*pharmacology
Cross-Over Studies
Double-Blind Method
Electrocardiography
Female
Gastric Acid/secretion
Gastric Mucosa/secretion
Gastrins/blood
Helicobacter Infections/drug therapy/*physiopathology
*Helicobacter pylori/isolation & purification
Humans
Hydrogen-Ion Concentration
Imidazoles/*pharmacology
Male
Omeprazole/*pharmacology
Proton Pumps/antagonists & inhibitors
Pyridines/*pharmacology
Stomach/chemistry/*drug effects/microbiology
Pubmed
Web of science
Création de la notice
25/01/2008 16:48
Dernière modification de la notice
20/08/2019 14:28