A comparison of six statins on the development of intimal hyperplasia in a human vein culture model.

Détails

ID Serval
serval:BIB_38E0063497D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A comparison of six statins on the development of intimal hyperplasia in a human vein culture model.
Périodique
European Journal of Vascular and Endovascular Surgery
Auteur⸱e⸱s
Corpataux J.M., Naik J., Porter K.E., London N.J.
ISSN
1078-5884
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
29
Numéro
2
Pages
177-181
Langue
anglais
Résumé
OBJECTIVE: Intimal hyperplasia (IH) threatens the patency of up to 35% of saphenous vein (SV) bypass grafts. In addition to reducing cholesterol levels, statins may modulate smooth muscle cell proliferation and migration. Statins inhibit matrix metalloproteinase (MMP) activity. We therefore investigated the effect of six statins on neointimal formation and MMP activity in human SV organ culture. STUDY DESIGN: Human SV specimens were cultured for 14 days in the presence of six different statins and subsequently processed for measurement of neointimal thickness and MMP activity. The drug concentrations chosen corresponded to the manufacturers' Cmax. RESULTS: The six statins all significantly reduced IH development (P = 0.004) in association with reduced expression of proMMP-2 and 9 (P = 0.03) and reduced activity of activated MMP-2 and 9 (P = 0.03). CONCLUSION: This study suggests that the potential benefit of statins in reducing IH is a class effect and not confined to specific statins. The reduction of IH produced by statins may in part be due to their inhibition of MMPs.
Mots-clé
Collagenases, Enzyme Precursors, Graft Occlusion, Vascular, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hyperplasia, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Saphenous Vein, Tissue Culture Techniques, Tunica Intima
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 10:01
Dernière modification de la notice
20/08/2019 14:28
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