Pulmonary nodules detected by thoracic computed tomography scan after exposure to asbestos: diagnostic significance.

Détails

ID Serval
serval:BIB_38A49E91C6FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pulmonary nodules detected by thoracic computed tomography scan after exposure to asbestos: diagnostic significance.
Périodique
International Journal of Tuberculosis and Lung Disease
Auteur⸱e⸱s
Clin B., Luc A., Morlais F., Paris C., Ameille J., Brochard P., De Girolamo J., Gislard A., Laurent F., Letourneux M., Schorle E., Launoy G., Pairon J.C.
Collaborateur⸱rice⸱s
National Network of Asbestos Post-Exposure Survey (APEXS)
Contributeur⸱rice⸱s
Badachi Y., Baron J., Beigelman C., Chamming's S., Conso F., Ferretti G., Jankowski A., Latrabe V., Montaudon M., Stoufflet A.
ISSN
1815-7920 (Electronic)
ISSN-L
1027-3719
Statut éditorial
Publié
Date de publication
2011
Volume
15
Numéro
12
Pages
1707-1714
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVE: To analyse the relationship between pulmonary nodules detected by radiologists using computed tomography and cumulative exposure to asbestos or asbestos-related pleuro-pulmonary diseases in 5662 asbestos-exposed subjects, and the relationship between pulmonary nodules and thoracic cancer, to determine whether a specific surveillance strategy based on cumulative asbestos exposure should be adopted.
DESIGN: Standardised incidence and mortality ratios (SIR) for lung cancer and pleural mesothelioma were calculated in patients with and without mention of pulmonary nodules and compared using comparative morbidity figures.
RESULTS: A significant excess incidence of primary lung cancer and pleural mesothelioma was observed among subjects presenting with pulmonary nodule(s) (SIR respectively 1.95, 95%CI 1.22-2.95, and 11.88, 95%CI 3.20-30.41). However, there was no significant relationship between pulmonary nodules mentioned by radiologists and cumulative asbestos exposure or between pulmonary nodules and the presence of asbestos-related benign diseases.
CONCLUSIONS: This study confirms the expected excess prevalence of lung cancer in subjects presenting with pulmonary nodules according to the radiologist's report, and shows the absence of relationship between the presence of nodules and level of cumulative asbestos exposure. Our study therefore offers no argument in favour of specific surveillance modalities based on estimated cumulative asbestos exposure.
Mots-clé
Aged, Asbestos/toxicity, Carcinogens/toxicity, Female, Humans, Incidence, Lung Neoplasms/chemically induced, Lung Neoplasms/pathology, Male, Mass Screening/methods, Mesothelioma/chemically induced, Mesothelioma/pathology, Middle Aged, Multiple Pulmonary Nodules/pathology, Multiple Pulmonary Nodules/radiography, Occupational Exposure/adverse effects, Pleural Neoplasms/chemically induced, Pleural Neoplasms/pathology, Population Surveillance, Prevalence, Solitary Pulmonary Nodule/pathology, Solitary Pulmonary Nodule/radiography, Tomography, X-Ray Computed/methods
Pubmed
Web of science
Création de la notice
07/05/2012 15:03
Dernière modification de la notice
20/08/2019 14:28
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