Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013.

Détails

ID Serval
serval:BIB_38940796536F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013.
Périodique
Clinical infectious diseases
Auteur⸱e⸱s
Tam J., Papenburg J., Fanella S., Asner S., Barton M., Bergeron C., Desai S., Hui C., Foo C., Langley J.M., Leifso K., Ma M.L., Pernica J., Robinson J., Singh R., Tapiero B., Allen U.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Statut éditorial
Publié
Date de publication
01/01/2019
Peer-reviewed
Oui
Volume
68
Numéro
1
Pages
113-119
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are <0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized with RSV infection in Canadian pediatric centers.
A retrospective case series of children aged ≤18 years with RSV-associated deaths at centers affiliated with the Pediatric Investigators Collaborative Network on Infections in Canada from 2003–2013, inclusive, was performed [corrected]. Cases were identified using RSV-specific International Classification of Diseases codes to capture deaths where a diagnosis of RSV infection was present.
Eleven centers reported 79 RSV-associated deaths. RSV was regarded as primarily responsible for death in 32 cases (40.5%). Median age at death was 11 months (range, <1 month to 16 years). Thirty-nine patients (49.4%) were male. Fourteen patients (17.7%) had no known risk factors for severe RSV infection. Healthcare-associated RSV infections (HAIs) accounted for 29 deaths (36.7%), with RSV judged to be the primary cause of death in 9 of these cases.
RSV-associated deaths were predominantly associated with chronic medical conditions and immunocompromised states among infants; however, 1 in 5 deaths occurred among patients with no known risk factors for severe RSV. Mortality associated with HAI accounted for over a third of cases. These findings highlight patient groups that should be targeted for RSV prevention strategies such as infection control practices, immunoprophylaxis, and future vaccination programs.
Mots-clé
Adolescent, Bronchiolitis/mortality, Canada/epidemiology, Child, Child, Preschool, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Pneumonia, Viral/mortality, Respiratory Syncytial Virus Infections/mortality, Retrospective Studies, Risk Factors, Survival Analysis
Pubmed
Web of science
Création de la notice
24/05/2018 16:36
Dernière modification de la notice
24/01/2020 6:19
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