The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task.

Détails

ID Serval
serval:BIB_3870F9FAD26B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task.
Périodique
Experimental Brain Research
Auteur(s)
Grasby P.M., Frith C.D., Paulesu E., Friston K.J., Frackowiak R.S., Dolan R.J.
ISSN
0014-4819 (Print)
ISSN-L
0014-4819
Statut éditorial
Publié
Date de publication
1995
Volume
104
Numéro
2
Pages
337-348
Langue
anglais
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal ArticlePublication Status: ppublish
Résumé
Scopolamine, a muscarinic antagonist, impairs memory performance in both humans and animals. In this study, repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers whilst performing auditory verbal memory tasks, before and after the administration of scopolamine (0.4 mg s.c.) or placebo. Compared to placebo, scopolamine increased blood flow in the lateral occipital cortex bilaterally and the left orbitofrontal region. Scopolamine decreased rCBF in the region of the right thalamus, the precuneus and the right and left lateral premotor areas. Scopolamine attenuated memory-task-induced increases of rCBF in the left and right prefrontal cortex and the right anterior cingulate region. These data suggest that acute blockade of cholinergic neurotransmission affects diverse brain areas, including components of the visual and motor systems, and, in addition, modulates memory task activations at distinct points in a distributed network for memory function.
Mots-clé
Adult, Brain/drug effects, Humans, Injections, Subcutaneous, Male, Memory/drug effects, Regional Blood Flow/drug effects, Scopolamine/pharmacology, Task Performance and Analysis, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
16/09/2011 21:07
Dernière modification de la notice
20/08/2019 14:27
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