Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma.
Détails
ID Serval
serval:BIB_38452DFE18C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma.
Périodique
HPB
Collaborateur⸱rice⸱s
EuroLVD and DRAGON Trials Collaborative
Contributeur⸱rice⸱s
Chevallier P., Wigmore S., Newhook T., Vauthey J.N., Memeo R., Dasari B.V., Braunwarth E., Aldrighetti L., van Baardewijk L., Barbier L., Binkert C., Björnsson B., Andorrà E.C., Arslan B., Baclija I., Bemelmans M., Bent C., de Boer M.T., Bokkers RPH, de Boo D., Breen D., Breitenstein S., Bruners P., Cappelli A., Carling U., Casellas I Robert M., Chan B., De Cobelli F., Cha C., Choi J., Crawford M., Croagh D., van Dam R., Deprez F., Detry O., Dewulf M., Díaz-Nieto R., Dili A., Erdmann J.I., Font J.C., Davis R., Delle M., Fernando R., Fisher O., Fouraschen S., Fretland Å.A., Fundora Y., Gelabert A., Gerard L., Gobardhan P., Gómez F., Guiliante F., Gruenberger T., Grochola L.F., Grünhagen D., Giménez J.G., Hagendoorn J., Heil J., Heise D., Herrero E., Hess G., Hilal M.A., Hoffmann M., Iezzi R., Imani F., Inmutto N., James S., Garcia Borobia F.J., Jovine E., Kalil J., Kingham P., Clarunis O.K., Kleeff J., van der Leij C., Lopez-Ben S., Macdonald A., Meijerink M., Korenblik R., Lapisatepun W., Leclercq W., Lindsay R., Lucidi V., Madoff D.C., Martel G., Mehrzad H., Menon K., Metrakos P., Modi S., Moelker A., Montanari N., Moragues J.S., López J.N., Neumann U., Nguyen J., Peddu P., Primrose J., Damink S.O., Qu X., Raptis D.A., Ratti F., Ryan S., Ridouani F., Borel Rinkes IHM, Rogan C., Ronellenfitsch U., Serenari M., Salik A., Sallemi C., Sandström P., Martin E.S., Sarría L., Schadde E., Serrablo A., Settmacher U., Smits J., Smits M., Snitzbauer A., Soonawalla Z., Sparrelid E., Spuentrup E., Stavrou G., Sutcliffe R., Tancredi I., Tasse J.C., Teichgräber U., Udupa V., Valenti D.A., Vass D., Vogl T., Wang X., White S., De Wispelaere J.F., Wohlgemuth W., Yu D., Zijlstra I.
ISSN
1477-2574 (Electronic)
ISSN-L
1365-182X
Statut éditorial
In Press
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Publication Status: aheadofprint
Résumé
Major hepatectomy in perihilar cholangiocarcinoma (pCCA) patients with a small future liver remnant (FLR) risks posthepatectomy liver failure (PHLF). This study examines combined portal and hepatic vein embolisation (PVE/HVE) to increase preoperative FLR volume and potentially decrease PHLF rates.
In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry. The study included pCCA patients who underwent PVE/HVE between July 2016 and January 2023.
Following PVE/HVE, 28% of patients (9/32) experienced complications, with 22% (7/32) necessitating biliary interventions for cholangitis. The median degree of hypertrophy after a median of 16 days was 16% with a kinetic growth rate of 6.8% per week. 69% of patients (22/32) ultimately underwent surgical resection. Cholangitis after PVE/HVE was associated with unresectability. After resection, 55% of patients (12/22) experienced complications, of which 23% (5/22) were Clavien-Dindo grade III or higher. The 90-day mortality after resection was 0%.
PVE/HVE quickly enhances the kinetic growth rate in pCCA patients. Cholangitis impairs chances on resection significantly. Resection after PVE/HVE is associated with low levels of 90-day mortality. The study highlights the potential of PVE/HVE in improving safety and outcomes in pCCA undergoing resection.
In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry. The study included pCCA patients who underwent PVE/HVE between July 2016 and January 2023.
Following PVE/HVE, 28% of patients (9/32) experienced complications, with 22% (7/32) necessitating biliary interventions for cholangitis. The median degree of hypertrophy after a median of 16 days was 16% with a kinetic growth rate of 6.8% per week. 69% of patients (22/32) ultimately underwent surgical resection. Cholangitis after PVE/HVE was associated with unresectability. After resection, 55% of patients (12/22) experienced complications, of which 23% (5/22) were Clavien-Dindo grade III or higher. The 90-day mortality after resection was 0%.
PVE/HVE quickly enhances the kinetic growth rate in pCCA patients. Cholangitis impairs chances on resection significantly. Resection after PVE/HVE is associated with low levels of 90-day mortality. The study highlights the potential of PVE/HVE in improving safety and outcomes in pCCA undergoing resection.
Pubmed
Création de la notice
20/09/2024 13:51
Dernière modification de la notice
21/09/2024 6:10
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