Angiotensin II is an endogenous neurotransmitter for rat and human mesenteric resistance blood vessels

Détails

ID Serval
serval:BIB_3843FD3D8FA0
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Angiotensin II is an endogenous neurotransmitter for rat and human mesenteric resistance blood vessels
Titre de la conférence
Joint Meeting of the Society for Microcirculation and Vascular Biology Swiss Society for Microcirculation
Auteur⸱e⸱s
Patil J., Heiniger E.v.a., Nussberger J., Schaffner T., Muehlemann O., Imboden H.
Adresse
Bern, Switzerland, Oct 08, 2009
ISBN
1018-1172
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
46
Série
Journal of Vascular Research
Pages
34-34
Langue
anglais
Notes
Meeting Abstract
Résumé
Angiotensin II (Ang II) is one of the most potent vasoconstrictors. We document here the innervation of rat and human mesenteric resistance arteries (MRA) by angiotensinergic neurons of the rat and human sympathetic coeliac ganglia. Angiotensinogen (Ang-N)-mRNA and angiotensin converting enzyme-mRNA but no renin-mRNA were detected by using quantitative real time polymerase chain reaction in total RNA extracts of rat coeliac ganglia. In the same extracts, cathepsin D-mRNA was detected: This protease also cleaves Ang I from Ang-N and could therefore account for the generation of neuronal Ang peptides in the absence of renin. In situ hybridization confirmed the presence of Ang-N-mRNA in the cytoplasm of rat coeliac ganglia. By using solid-phase extraction, high performance liquid chromatography and subsequent radioimmunoassay, Ang II and its metabolites were detected in rat and also in human coeliac ganglia. Immunoreactivity for Ang II was demonstrated in rat and human coeliac ganglia neurons and their projections innervating MRA. In addition, segmental angiotensinergic innervation of MRA was also observed. By means of confocal laser scanning microscopy we were able to demonstrate the presence of angiotensinergic synapses en passant along side of vascular smooth muscle cells. Our findings could indicate that Ang II is synthesized inside the neurons of sympathetic coeliac ganglia and may act as an endogenous neurotransmitter locally in MRA.
Web of science
Création de la notice
27/10/2009 14:45
Dernière modification de la notice
20/08/2019 13:27
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