Venous thromboembolism (VTE) is one of the leading causes of mortality and morbidity worldwide, and its diagnosis and risk stratification remain a challenge. Therapy and follow-up are also essential in the management of this pathology. The aim of this article is to summarize the most recent recommendations in the diagnostic pathway, risk stratification and follow-up of the more severe and frequent forms of VTE, pulmonary embolism and deep vein thrombosis of the lower limbs.