Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_3807FCACE3C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis.
Périodique
Diagnostics
Auteur(s)
Ballova V., Muoio B., Albano D., Bertagna F., Canziani L., Ghielmini M., Ceriani L., Treglia G.
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Statut éditorial
Publié
Date de publication
12/02/2020
Peer-reviewed
Oui
Volume
10
Numéro
2
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Some studies evaluated the diagnostic performance of fluorine-18-fluorodeoxyglucose ( <sup>18</sup> F-FDG) positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) for the detection of post-transplant lymphoproliferative disorder (PTLD). As there is no clear consensus about the diagnostic accuracy of these imaging methods, we performed a meta-analysis on this topic.
A comprehensive computer literature search of PubMed, Embase, and Cochrane library databases through December 2019 was performed. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and diagnostic odds ratio (DOR) of <sup>18</sup> F-FDG PET or PET/CT for detection of PTLD were calculated.
Five studies reporting data on the diagnostic performance of <sup>18</sup> F-FDG PET or PET/CT in 336 transplant recipients were included in the systematic review and bivariate meta-analysis. Pooled sensitivity and specificity for detection of PTLD were 89.7% (95% confidence interval (95%CI): 84.6-93.2%) and 90.9% (95%CI: 85.9-94.3%), respectively. Pooled LR+, LR-, and DOR were 8.9 (95%CI: 5.7-14), 0.13 (95%CI: 0.08-0.2), and 70.4 (95%CI: 35.4-140), respectively. A significant heterogeneity among studies was not detected.
Despite limited literature data, <sup>18</sup> F-FDG PET or PET/CT demonstrated good diagnostic performance for the detection of PTLD, but large prospective studies are needed to strengthen these findings.
Mots-clé
18F-FDG, PET, PTLD, lymphoma, meta-analysis, post-transplant lymphoproliferative disorder
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/02/2020 17:44
Dernière modification de la notice
15/01/2021 8:08
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