Assessing the role of cingulate cortex in bipolar disorder: neuropathological, structural and functional imaging data

Détails

ID Serval
serval:BIB_37931C2BBEF6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Assessing the role of cingulate cortex in bipolar disorder: neuropathological, structural and functional imaging data
Périodique
Brain Research Reviews
Auteur⸱e⸱s
Fountoulakis Konstantinos N., Giannakopoulos Panteleimon, Kövari Enikö, Bouras Constantin
ISSN
0165-0173
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
59
Numéro
1
Pages
9-21
Langue
anglais
Notes
SAPHIRID:70506
Résumé
Objectives: Most of the neuroanatomical models of bipolar disorder (BD) propose a key role for the anterior cingulate cortex (ACC). We provide here a review of currently available data regarding the CC neuroimaging and neuropathological alterations in BD. Materials and methods: After an exploratory search of the MEDLINE, we first identified all English-written articles that provide separate data for BD patients and report original experimental data on cingulate gyrus. Subsequently, we selected those including neuroimaging or neuropathological data. Among the 161 articles updated through June 2007, 81 articles were retained using this procedure. Results: The review of in vivo volumetric imaging data, as well as ex vivo morphometric and histological studies indicates that BD patients show volume changes of the subgenual ACC (sgACC-BA 25 and part of 24) during the early stages of the disease. Whether this phenomenon is due to neuronal and glial depletion or damage of corticocortical connections is still a matter of debate. The resting state activity in the left BA 25 appears to be state dependent showing significant increase during mania and decrease during depressive phases. The presence of a deficient GABAergic activity in ACC is also documented. Pharmacological treatment partly restores BD-related functional imaging changes. Conclusion: The present review reveals the striking discrepancies of the experimental results present both for functional and structural imaging studies but also for neuropathological analyses. Methodological and conceptual limitations are addressed with particular reference to the heterogeneity of BD clinical patterns. We also critically discuss the validity of CC changes as possible trait- or state-markers of the disease.
Pubmed
Web of science
Création de la notice
18/11/2008 12:24
Dernière modification de la notice
20/08/2019 14:26
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