The evolution of severe steatosis after bariatric surgery is related to insulin resistance.

Détails

ID Serval
serval:BIB_36A1069AD85D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The evolution of severe steatosis after bariatric surgery is related to insulin resistance.
Périodique
Gastroenterology
Auteur(s)
Mathurin P., Gonzalez F., Kerdraon O., Leteurtre E., Arnalsteen L., Hollebecque A., Louvet A., Dharancy S., Cocq P., Jany T., Boitard J., Deltenre P., Romon M., Pattou F.
ISSN
0016-5085 (Print)
ISSN-L
0016-5085
Statut éditorial
Publié
Date de publication
2006
Volume
130
Numéro
6
Pages
1617-1624
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
BACKGROUND & AIMS: In severely obese patients, factors implicated in the evolution of severe steatosis after bariatric surgery remain unresolved. Our aim was to determine whether insulin resistance (IR) influences the histologic effects induced by bariatric surgery.
METHODS: We prospectively included 185 severely obese patients (body mass index >/=35 kg/m(2)) referred for bariatric surgery. The evolution of IR (IR index = 1/quantitative insulin sensitivity check index) and liver injury with consecutive biopsy was concomitantly assessed before and 1 year after surgery.
RESULTS: At preoperative biopsy, 27% of severely obese patients disclosed severe steatosis (>/=60%). The alanine aminotransferase (P = .01) and IR indexes (P = .04) were independent predictive factors of severe steatosis at baseline. One year after surgery, surgical treatment induced a decrease in body mass index (9.5 kg/m(2); P < .0001), steatosis score (8.5%; P < .0001), and IR index (0.29; P < .0001). The preoperative IR index (P = .01) and preoperative steatosis (P = .006) were independent predictive factors in the persistence of severe steatosis after surgery. Moderate or severe steatosis was more frequently observed in patients who had conserved a higher IR index after surgery than in patients who had improved their IR index (44% vs 20.2%; P = .04).
CONCLUSIONS: IR was independently associated with severe steatosis and predicted its persistence after surgery. The amelioration of IR after surgery is associated with a decrease in the amount of fat. Taken together, the results of this prospective study in severely obese patients demonstrate that severe steatosis and its evolution after surgery are intimately connected with IR.
Mots-clé
Adult, Analysis of Variance, Body Mass Index, Cohort Studies, Fatty Liver/etiology, Fatty Liver/pathology, Female, Follow-Up Studies, Gastric Bypass/adverse effects, Gastric Bypass/methods, Humans, Insulin Resistance, Laparoscopy/adverse effects, Laparoscopy/methods, Logistic Models, Male, Obesity, Morbid/diagnosis, Obesity, Morbid/surgery, Postoperative Care, Predictive Value of Tests, Preoperative Care, Probability, Prospective Studies, Risk Assessment, Severity of Illness Index, Treatment Outcome
Pubmed
Web of science
Création de la notice
06/12/2013 11:22
Dernière modification de la notice
20/08/2019 14:24
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