Therapeutic vaccines and immunological intervention in HIV infection: a paradigm change.

Détails

ID Serval
serval:BIB_369C392ACCBE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Therapeutic vaccines and immunological intervention in HIV infection: a paradigm change.
Périodique
Current opinion in HIV and AIDS
Auteur(s)
Pantaleo G., Levy Y.
ISSN
1746-6318 (Electronic)
ISSN-L
1746-630X
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
11
Numéro
6
Pages
576-584
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The purpose is to review current knowledge of immunological interventions in HIV infection and discuss strategies for the establishment of functional cure and/or HIV eradication.
Therapeutic vaccines and cytokines have been historically the immunological interventions developed with the objective to enhance the HIV-specific cell-mediated immune responses and to suppress virus replication. Both these interventions have shown only partial antiviral effects. The recent identification and generation of human broad neutralizing antibodies provides potent immunological intervention associated with effective suppression of virus replication in the absence of antiretroviral therapy. Furthermore, the identification that the major HIV cell reservoir containing replication competent and infectious virus is composed by programed cell death protein 1 (PD-1) positive memory CD4 T cells offers the opportunity to target directly the HIV cell reservoir with anti-PD-1 antibodies. Anti-PD-1 antibody therapy may be also critical to prevent exhaustion of CD8 T cells.
The availability of a diverse armamentarium of immunological intervention offers the opportunity to investigate the efficacy of the combined use of different immunological interventions in inducing prolonged virus suppression in the absence of antiretroviral therapy and functional cure HIV or HIV eradication.

Mots-clé
AIDS Vaccines/therapeutic use, Combined Modality Therapy/methods, HIV Infections/therapy, Humans, Immunotherapy/methods
Pubmed
Web of science
Création de la notice
23/09/2016 19:59
Dernière modification de la notice
20/08/2019 14:24
Données d'usage