Morphometric correlates of anomia in patients with small left temporopolar lesions.

Détails

ID Serval
serval:BIB_369B4078424E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Morphometric correlates of anomia in patients with small left temporopolar lesions.
Périodique
Journal of neuropsychology
Auteur⸱e⸱s
Alemán-Gómez Y., Poch C., Toledano R., Jiménez-Huete A., García-Morales I., Gil-Nagel A., Campo P.
ISSN
1748-6653 (Electronic)
ISSN-L
1748-6645
Statut éditorial
Publié
Date de publication
06/2020
Peer-reviewed
Oui
Volume
14
Numéro
2
Pages
260-282
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Visual object naming is a complex cognitive process that engages an interconnected network of cortical regions moving from occipitotemporal to anterior-inferior temporal cortices, and extending into the inferior frontal cortex. Naming can fail for diverse reasons, and different stages of the naming multi-step process appear to be reliant upon the integrity of different neuroanatomical locations. While the neural correlates of semantic errors have been extensively studied, the neural basis of omission errors remains relatively unspecified. Although a strong line of evidence supports an association between anterior temporal lobe damage and semantic errors, there are some studies suggesting that the anterior temporal lobe could be also associated with omissions. However, support for this hypothesis comes from studies with patients in whom damage affected extensive brain regions, sometimes bilaterally. Here, we availed of a group of 12 patients with epilepsy associated with a small lesion at the tip of the left temporal pole. Using an unbiased surface-based morphometry methodology, we correlated two morphological features with errors observed during visual naming. Analyses revealed a correlation between omission errors and reduced local gyrification index in three cortical clusters: one in the left anteromedial temporal lobe region (AMTL) and two in the left anterior cingulate cortex (ACC). Our findings support the view that regions in ACC and AMTL are critical structures within a network engaged in word selection from semantics.
Mots-clé
Adult, Anomia/physiopathology, Brain Mapping, Epilepsy, Temporal Lobe/physiopathology, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Semantics, Temporal Lobe/physiopathology, Young Adult, anomia, anterior temporal cortex, brain morphometry, epilepsy, visual naming
Pubmed
Web of science
Création de la notice
14/05/2019 13:37
Dernière modification de la notice
14/07/2021 5:39
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