What can be learned from the experience with the fixed low-dose combination of perindopril/indapamide in the treatment of hypertension?

Détails

ID Serval
serval:BIB_36882
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
What can be learned from the experience with the fixed low-dose combination of perindopril/indapamide in the treatment of hypertension?
Périodique
Expert Opinion on Pharmacotherapy
Auteur⸱e⸱s
Waeber B.
ISSN
1744-7666
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
6
Numéro
13
Pages
2291-2299
Langue
anglais
Notes
Publication types: Comparative Study
Résumé
The association of low doses of perindopril and indapamide in a single pill has been developed to meet the criteria required for a fixed-dose combination to be used as first-line therapy. The experience accumulated so far has demonstrated a greater antihypertensive efficacy of this preparation compared with various monotherapies, but not at the expense of a worsening of tolerability. The perindopril/indapamide combination is particularly effective in lowering systolic and pulse blood pressure. Starting treatment with this fixed-dose combination improves arterial stiffness and allows a better regression of cardiac hypertrophy than angiotensin-converting enzyme-inhibition or beta-adrenoceptor blockade alone. In hypertensive patients with Type 2 diabetes, a greater reduction of urinary albumin excretion can be obtained with the perindopril/indapamide association compared with an angiotensin-converting enzyme inhibitor administered as monotherapy. There is evidence that a first-line management of hypertension based on a low-dose perindopril/indapamide combination can provide a better efficacy/safety ratio than other well-established therapeutic strategies.
Mots-clé
Administration, Oral, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Diabetes Mellitus, Type 2, Diuretics, Drug Administration Schedule, Drug Combinations, Heart Diseases, Humans, Hypertension, Indapamide, Kidney Diseases, Perindopril
Pubmed
Web of science
Création de la notice
19/11/2007 12:35
Dernière modification de la notice
20/08/2019 13:24
Données d'usage