What can be learned from the experience with the fixed low-dose combination of perindopril/indapamide in the treatment of hypertension?
Détails
ID Serval
serval:BIB_36882
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
What can be learned from the experience with the fixed low-dose combination of perindopril/indapamide in the treatment of hypertension?
Périodique
Expert Opinion on Pharmacotherapy
ISSN
1744-7666
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
6
Numéro
13
Pages
2291-2299
Langue
anglais
Notes
Publication types: Comparative Study
Résumé
The association of low doses of perindopril and indapamide in a single pill has been developed to meet the criteria required for a fixed-dose combination to be used as first-line therapy. The experience accumulated so far has demonstrated a greater antihypertensive efficacy of this preparation compared with various monotherapies, but not at the expense of a worsening of tolerability. The perindopril/indapamide combination is particularly effective in lowering systolic and pulse blood pressure. Starting treatment with this fixed-dose combination improves arterial stiffness and allows a better regression of cardiac hypertrophy than angiotensin-converting enzyme-inhibition or beta-adrenoceptor blockade alone. In hypertensive patients with Type 2 diabetes, a greater reduction of urinary albumin excretion can be obtained with the perindopril/indapamide association compared with an angiotensin-converting enzyme inhibitor administered as monotherapy. There is evidence that a first-line management of hypertension based on a low-dose perindopril/indapamide combination can provide a better efficacy/safety ratio than other well-established therapeutic strategies.
Mots-clé
Administration, Oral, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Diabetes Mellitus, Type 2, Diuretics, Drug Administration Schedule, Drug Combinations, Heart Diseases, Humans, Hypertension, Indapamide, Kidney Diseases, Perindopril
OAI-PMH
Pubmed
Web of science
Création de la notice
19/11/2007 12:35
Dernière modification de la notice
20/08/2019 13:24