Primary motor cortex inhibition in spinal cord injuries.

Détails

ID Serval
serval:BIB_366567E0FF91
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Primary motor cortex inhibition in spinal cord injuries.
Périodique
Neuro Endocrinology Letters
Auteur(s)
Kriz J., Kozak J., Zedka M.
ISSN
0172-780X (Print)
ISSN-L
0172-780X
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
33
Numéro
4
Pages
431-441
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication
Résumé
OBJECTIVES AND METHODS: Excitability changes in the primary motor cortex in 17 spinal-cord injured (SCI) patients and 10 controls were studied with paired-pulse transcranial magnetic stimulation. The paired pulses were applied at inter-stimulus intervals (ISI) of 2 ms and 15 ms while motor evoked potentials (MEP) were recorded in the biceps brachii (Bic), the abductor pollicis brevis (APB) and the tibialis anterior (TA) muscles.
RESULTS: The study revealed a significant decrease in cortical motor excitability in the first weeks after SCI concerning the representation of both the affected muscles innervated from spinal segments below the lesion, and the spared muscles rostral to the lesion. In the patients with motor-incomplete injury, but not in those with motor-complete injury, the initial cortical inhibition of affected muscles was temporarily reduced 2-3 months following injury. The degree of inhibition in cortical areas representing the spared muscles was observed to be smaller in patients with no voluntary TA activity compared to patients with some activity remaining in the TA. Surprisingly, motor-cortical inhibition was observed not only at ISI 2 ms but also at ISI 15 ms. The inhibition persisted in patients who returned for a follow-up measurement 2-3 years later.
CONCLUSION: The present data showed different evaluation of cortical excitability between patients with complete and incomplete spinal cord lesion. Our results provide more insight into the pathophysiology of SCI and contribute to the ongoing discussion about the recovery process and therapy of SCI patients.
Pubmed
Web of science
Création de la notice
29/11/2012 18:19
Dernière modification de la notice
20/08/2019 13:24
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