Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study.

Détails

Ressource 1Télécharger: 5_28634642_Postprint.pdf (730.80 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_364079609B9A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study.
Périodique
European journal of clinical pharmacology
Auteur(s)
Abolhassani N., Castioni J., Marques-Vidal P., Vollenweider P., Waeber G.
ISSN
1432-1041 (Electronic)
ISSN-L
0031-6970
Statut éditorial
Publié
Date de publication
09/2017
Peer-reviewed
Oui
Volume
73
Numéro
9
Pages
1187-1194
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
This study aimed to assess the prevalence, the change, and the determinants of change in polypharmacy in a population-based sample.
Baseline (2003-2006) and follow-up (2009-2012) data are from 4679 participants aged between 35 and 75 years (53.5% women, mean age 52.6 ± 10.6 years) from the population of Lausanne, Switzerland. Polypharmacy was defined by the regular use of ≥5 drugs. Four categories of change were defined: never (no polypharmacy at baseline and follow-up), initiating (no polypharmacy at baseline but at follow-up), maintaining, or quitting.
Polypharmacy increased from 7.7% at baseline to 15.3% at follow-up. Cardiovascular drugs were the most prescribed medicines at baseline and follow-up. Gender, age, obesity, smoking, previously diagnosed hypertension, or diabetes or dyslipidemia were significantly and independently associated with initiating and maintaining polypharmacy.
In a population-based sample, prevalence of polypharmacy doubled over a 5.6-year period. The main determinants of initiating polypharmacy were age, overweight and obesity, smoking status, and previously diagnosed cardiovascular risk factors.

Mots-clé
Adult, Aged, Analgesics/therapeutic use, Cardiovascular Agents/therapeutic use, Diabetes Mellitus/drug therapy, Diabetes Mellitus/epidemiology, Dyslipidemias/drug therapy, Dyslipidemias/epidemiology, Female, Humans, Hypertension/drug therapy, Hypertension/epidemiology, Hypoglycemic Agents/therapeutic use, Life Style, Male, Middle Aged, Overweight/drug therapy, Overweight/epidemiology, Polypharmacy, Prevalence, Psychotropic Drugs/therapeutic use, Risk Factors, Smoking/drug therapy, Smoking/epidemiology, Switzerland/epidemiology, Determinants, General population, Switzerland, Trends
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/06/2017 7:35
Dernière modification de la notice
20/08/2019 13:24
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