Elevation of Postmortem Cerebrospinal Fluid Sodium and Chloride Levels Is a Potential Adjunct Test in the Diagnosis of Salt Water Drowning.

Détails

ID Serval
serval:BIB_36139EA42054
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Elevation of Postmortem Cerebrospinal Fluid Sodium and Chloride Levels Is a Potential Adjunct Test in the Diagnosis of Salt Water Drowning.
Périodique
The American journal of forensic medicine and pathology
Auteur⸱e⸱s
Garland J., McCarthy S., Hensby-Bennett S., Philcox W., OʼRegan T., Rousseau G., Palmiere C., Elstub H., Cala A., Clifton L., Lam L., Barker C., Ondruschka B., Woydt L., Spark A., Kesha K., Morrow P., Glenn C., Stables S., Tse R.
ISSN
1533-404X (Electronic)
ISSN-L
0195-7910
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
40
Numéro
3
Pages
251-257
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Postmortem vitreous humor biochemistry is a useful test in the diagnosis of salt water drowning (SWD). A significant limitation of vitreous humor is the potential effect of prolonged immersion. A recent animal study and case report suggested that cerebrospinal fluid biochemistry may be an alternative to vitreous because it is more resistant to the effects of immersion, given its protected anatomical location. This study compared postmortem cerebrospinal fluid sodium and chloride (PMCSC) levels collected via ventricular aspiration (PMCSC_V) and via lumbar puncture (PMCSC_L) in 13 SWD and 31 nonimmersion deaths. It showed a significant elevation in PMCSC levels in SWD deaths for both PMCSC_V and PMCSC_L (P < 0.05). The areas under the curve on the receiver operating characteristic curves for PMCSC_V and PMCSC_L were 0.73 and 0.83, respectively. The optimal cutoff for PMCSC_V was 216 mmol/L (sensitivity, 0.60; specificity, 0.72; likelihood ratio, 1.80; positive predictive value, 0.45) and for PMCSC_L was 241 mmol/L (sensitivity, 0.78; specificity, 0.73; likelihood ratio, 2.89; positive predictive value, 0.46). This study supports PMCSC levels as another biochemical test that can potentially aid in the diagnosis of SWD, particularly in cases where vitreous humor samples are unavailable or uninterpretable.
Mots-clé
Adult, Aged, Aged, 80 and over, Biomarkers/cerebrospinal fluid, Case-Control Studies, Chlorides/cerebrospinal fluid, Drowning/diagnosis, Female, Forensic Medicine/methods, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Seawater, Sensitivity and Specificity, Sodium/cerebrospinal fluid, Young Adult
Pubmed
Web of science
Création de la notice
25/05/2019 13:17
Dernière modification de la notice
12/09/2019 5:10
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