Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma.

Détails

ID Serval
serval:BIB_3607431B225B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma.
Périodique
Cancer Research
Auteur(s)
Mach J.P., Chatal J.F., Lumbroso J.D., Buchegger F., Forni M., Ritschard J., Berche C., Douillard J.Y., Carrel S., Herlyn M., Steplewski Z., Koprowski H.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
1983
Volume
43
Numéro
11
Pages
5593-5600
Langue
anglais
Résumé
A radiolabeled monoclonal antibody (MAb) that has been shown to react specifically in vitro and ex vivo to human colorectal carcinoma and to inhibit growth of human carcinomas grafted in nude mice was administered to 52 colorectal carcinoma patients and 15 patients with other types of cancer. Of 63 colorectal carcinoma tumor sites studied, 34 showed significant accumulation of antibody by external photoscanning and tomoscintigraphy, whereas none of the 20 sites of other cancer types gave positive results. One-third of the patients received F(ab')2 fragments of the MAb, which gave a slightly higher percentage (61%) of positive results than did intact MAbs (51%). A few patients scheduled for tumor resection were given injections simultaneously of 131I-labeled MAb and 125I-labeled normal immunoglobulin G. Antibody concentration in resected tumors was 3.6 to 6.3 times higher than the average antibody concentration in adjacent normal tissues (1.5, 3.4, and 9.4 as compared with normal mucosa, serosa, and fat, respectively), and the specificity indices, calculated by differential radioactivity analysis, ranged from 2.1 to 5.1. The results show the potential value and limitations of this particular MAb for tumor detection by immunoscintigraphy.
Mots-clé
Antibodies, Monoclonal, Antigen-Antibody Complex, Antigens, Neoplasm/analysis, Antigens, Surface/analysis, Colonic Neoplasms/immunology, Colonic Neoplasms/radionuclide imaging, Humans, Immunoglobulin G/analysis, Iodine Radioisotopes/diagnostic use, Kinetics, Neoplasms/immunology, Rectal Neoplasms/immunology, Rectal Neoplasms/radionuclide imaging
Pubmed
Web of science
Création de la notice
25/04/2013 13:58
Dernière modification de la notice
20/08/2019 13:23
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