Posttransplant lymphoproliferative disorder after liver transplantation in miniature swine.

Détails

ID Serval
serval:BIB_35A74581C38A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Posttransplant lymphoproliferative disorder after liver transplantation in miniature swine.
Périodique
Transplantation
Auteur(s)
Talpe S., Oike F., Dehoux J.P., Sempoux C., Rahier J., Otte J.B., Gianello P.
ISSN
0041-1337 (Print)
ISSN-L
0041-1337
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
71
Numéro
11
Pages
1684-1688
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
PDF: Brief Communication
Résumé
BACKGROUND: Posttransplant lymphoproliferative disorder (PTLD) is a well-known, life-threatening complication of immunosuppressive therapy, occurring in both adult and pediatric transplant recipients.
METHODS: To study the effect of major histocompatibility complex on tolerance induction to primarily vascularized liver allograft, a semi-identical miniature swine model was developed to mimic the clinical situation of parent-into-infant liver transplantation. Long-term acceptance of semi-identical liver allograft was obtained by a transient course of FK506. In a subgroup of six animals, three developed a lethal PTLD. These animals were studied by histology and immunohistochemistry and the anti-donor cellular immune response was assessed. In addition, the possible viral origin of the proliferative process was evoked.
RESULTS: Histology and immunohistochemistry revealed an abnormal B-cell proliferation in many organs of swine suffering from PTLD. Evidence of human Epstein-Barr virus, cytomegalovirus, and adenovirus was not evidenced, but a porcine virus responsible for a respiratory and reproductive syndrome (PRRS) was identified in the lymphoid tissue of these animals. In mixed lymphocyte reaction, a significant antiself immune response confirmed an infection by a virus.
CONCLUSIONS: This is the first report suggesting that PRRS virus might provoke PTLD in immunosuppressed miniature swine after orthotopic liver transplantation. Whether PTLD could be induced by injection of the PRRS virus in immunosuppressed animals, a pig model of PTLD might be developed and would represent an interesting preclinical model for testing anti-PTLD therapies.
Mots-clé
Animals, Immunohistochemistry, Immunosuppression/adverse effects, Liver Transplantation/adverse effects, Lymphocyte Culture Test, Mixed, Lymphoid Tissue/virology, Lymphoproliferative Disorders/metabolism, Lymphoproliferative Disorders/mortality, Porcine Reproductive and Respiratory Syndrome/diagnosis, Porcine Reproductive and Respiratory Syndrome/virology, Porcine respiratory and reproductive syndrome virus/isolation & purification, Swine, Swine, Miniature
Pubmed
Web of science
Création de la notice
20/10/2016 17:32
Dernière modification de la notice
20/08/2019 14:23
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