Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism

Détails

ID Serval
serval:BIB_355476DC83EA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism
Périodique
Annals of Neurology
Auteur(s)
Vingerhoets  F. J., Snow  B. J., Lee  C. S., Schulzer  M., Mak  E., Calne  D. B.
ISSN
0364-5134 (Print)
Statut éditorial
Publié
Date de publication
11/1994
Volume
36
Numéro
5
Pages
759-64
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Previous estimates of the rate of progression of the nigral pathology underlying idiopathic parkinsonism (IP) have been derived mainly from pathological studies that have an inherent selection bias. Fluorodopa positron emission tomography (PET) is a reliable tool for assessing nigrostriatal dopaminergic function in vivo. We performed fluorodopa PET on two occasions, 7 years apart, on 16 patients with IP (age at the time of the first scan, 51 +/- 14 yr [mean +/- SD]) and 10 normal controls (age, 54 +/- 16 yr). For the patients with IP, the average duration of symptoms from the time of diagnosis to the first scan was 4.5 years (range, 1-12 yr); their PET index (striatal-occipital)/occipital ratio, dropped by 1.7% per year, from 0.49 +/- 0.08 to 0.43 +/- 0.08 (p < 0.001). The normals' ratio decreased by 0.3% per year from 0.77 +/- 0.05 to 0.75 +/- 0.10 (p = 0.33). The ratios in the IP group progressed significantly faster than the controls (p = 0.036). The rate of decline in IP represents 7.8% per decade, expressed as a fraction of the normals' initial mean value at 54 years of age. These results also permit power analysis for the design of future studies assessing the effect of treatment on the underlying pathology in IP.
Mots-clé
Adult Aged Dihydroxyphenylalanine/*analogs & derivatives/diagnostic use Disease Progression Female Humans Male Middle Aged Parkinson Disease/*radionuclide imaging Substantia Nigra/radionuclide imaging Tomography, Emission-Computed/*methods
Pubmed
Web of science
Création de la notice
25/01/2008 13:48
Dernière modification de la notice
20/08/2019 14:22
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