Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design.

Détails

ID Serval
serval:BIB_3553A9673745
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design.
Périodique
Alzheimer's research & therapy
Auteur⸱e⸱s
Ribaldi F., Chicherio C., Altomare D., Martins M., Tomczyk S., Jelescu I., Maturana E., Scheffler M., Haller S., Lövblad K.O., Pievani M., Garibotto V., Kliegel M., Frisoni G.B.
ISSN
1758-9193 (Electronic)
Statut éditorial
Publié
Date de publication
25/05/2021
Peer-reviewed
Oui
Volume
13
Numéro
1
Pages
105
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative diseases (such as Alzheimer's disease, AD), minor psychiatric conditions, neurological, and/or somatic comorbidities. Even if a theoretical framework has been established, the etiology of SCD remains far from elucidated. Clinical observations recently lead to the hypothesis that individuals with incipient AD may have overestimated metacognitive judgements of their own cognitive performance, while those with psychiatric disorders typically present underestimated metacognitive judgements. Moreover, brain connectivity changes are known correlates of AD and psychiatric conditions and might be used as biomarkers to discriminate SCD individuals of different etiologies. The aim of the COSCODE study is to identify metacognition, connectivity, behavioral, and biomarker profiles associated with different etiologies of SCD. Here we present its rationale and study design.
COSCODE is an observational, longitudinal (4 years), prospective clinical cohort study involving 120 SCD, and 80 control study participants (40 individuals with no cognitive impairment, and 40 living with mild cognitive impairment - MCI, or dementia due to AD), all of which will undergo diffusion magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) as well as behavioral and biomarker assessments at baseline and after 1 and 2 years. Both hypothesis-driven and data-driven cluster analysis approaches will be used to identify SCD sub-types based on metacognition, connectivity, behavioral, and biomarker features.
COSCODE will allow defining and interpreting the constellation of signs and symptoms associated with different etiologies of SCD, paving the way to the development of cost-effective risk assessment and prevention protocols.
Mots-clé
Brain/diagnostic imaging, Cognitive Dysfunction/diagnostic imaging, Cohort Studies, Humans, Metacognition, Neuropsychological Tests, Prospective Studies, Alzheimer’s disease biomarkers, Connectivity, Subjective cognitive decline
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/05/2021 8:31
Dernière modification de la notice
06/01/2024 8:13
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