Molecular genetics of dysplasia in ulcerative colitis

Détails

ID Serval
serval:BIB_3514591A28D0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecular genetics of dysplasia in ulcerative colitis
Périodique
European Journal of Cancer
Auteur(s)
Benhattar  J., Saraga  E.
ISSN
0959-8049 (Print)
Statut éditorial
Publié
Date de publication
1995
Volume
31A
Numéro
7-8
Pages
1171-1173
Notes
PT - Journal Article PT - Review
Résumé
Numerous molecular genetic events occurring in the development of sporadic colorectal neoplasia have been previously defined. The most frequent genetic alterations are mutations of the APC, KRAS, and TP53 genes, as well as loss of the DCC gene and of the second TP53 allele. The data from several groups indicate that these genes play an important role in ulcerative colitis-associated dysplasias and cancer, as they do in sporadic colorectal adenomas and carcinomas. KRAS and TP53 mutations were detected in dysplasia, but also in villous regeneration and active colitis, and affect a subpopulation of the cells composing these lesions. We conclude that in histologically defined dysplasia, clones can be found that genetically represent precancerous lesions in ulcerative colitis. Seen in this way, part of the active colitis and villous regeneration lesions might be considered as preneoplastic. When present, KRAS mutation is an excellent genetic marker to map populations of preneoplastic cells
Mots-clé
Cell Transformation,Neoplastic/genetics/Colitis,Ulcerative/Colorectal Neoplasms/Genes,p53/Genes,ras/Humans/Precancerous Conditions
Pubmed
Web of science
Création de la notice
29/01/2008 18:36
Dernière modification de la notice
20/08/2019 13:22
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