Correlating HIV tropism with immunological response under combination antiretroviral therapy.

Détails

ID Serval
serval:BIB_34F6E591ED44
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Correlating HIV tropism with immunological response under combination antiretroviral therapy.
Périodique
HIV medicine
Auteur(s)
Bader J., Schöni-Affolter F., Böni J., Gorgievski-Hrisoho M., Martinetti G., Battegay M., Klimkait T.
Collaborateur(s)
Swiss HIV Cohort Study
Contributeur(s)
Aubert V., Bernasconi E., Bucher H., Burton-Jeangros C., Calmy A., Cavassini M., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C., Günthard H., Haerry D., Hasse B., Hirsch H., Hoffmann M., Hösli I., Kahlert C., Kaiser L., Keiser O., Kouyos R., Kovari H., Ledergerber B., de Tejada B.M., Metzner K., Müller N., Nadal D., Nicca D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schüpbach J., Speck R., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Statut éditorial
Publié
Date de publication
09/2016
Peer-reviewed
Oui
Volume
17
Numéro
8
Pages
615-622
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART). It is still unclear whether viral properties such as cell tropism play a major role in this incomplete immune response. This study therefore intended to follow the tropism evolution of the HIV-1 envelope during periods of suppressive cART.
Viruses from two distinct patient groups, one with good and another one with poor CD4 recovery after 5 years of suppressive cART, were genotypically analysed for viral tropism at baseline and at the end of the study period.
Patients with CCR5-tropic CC-motif chemokine receptor 5 viruses at baseline tended to maintain this tropism to the study end. Patients who had a CXCR4-tropic CXC-motif chemokine receptor 4 virus at baseline were overrepresented in the poor CD4 recovery group. Overall, however, the majority of patients presented with CCR5-tropic viruses at follow-up.
Our data lend support to the hypothesis that tropism determination can be used as a parameter for disease progression even if analysed long before the establishment of a poorer immune response. Moreover, the lasting predominating CCR5-tropism during periods of full viral control suggests the involvement of cellular mechanisms that preferentially reduce CXCR4-tropic viruses during cART.

Mots-clé
Adult, Aged, Anti-Retroviral Agents/therapeutic use, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cohort Studies, Female, Genotyping Techniques, HIV Infections/drug therapy, HIV Infections/immunology, HIV Infections/virology, HIV-1/genetics, HIV-1/physiology, Humans, Male, Middle Aged, Treatment Outcome, Viral Tropism, HIV, antiretroviral therapy, combination, immune response, tropism
Pubmed
Web of science
Création de la notice
16/02/2016 17:46
Dernière modification de la notice
20/08/2019 13:22
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