Gastric banding induces negative bone remodelling in the absence of secondary hyperparathyroidism: potential role of serum C telopeptides for follow-up.

Détails

ID Serval
serval:BIB_34F678B736DA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gastric banding induces negative bone remodelling in the absence of secondary hyperparathyroidism: potential role of serum C telopeptides for follow-up.
Périodique
International journal of obesity (2005)
Auteur(s)
Giusti V., Gasteyger C., Suter M., Heraief E., Gaillard R.C., Burckhardt P.
ISSN
0307-0565
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
29
Numéro
12
Pages
1429-35
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article - Publication Status: ppublish
Résumé
OBJECTIVE: Data about the consequences of laparoscopic adjustable gastric banding (LAGB) on phospho-calcic and bone metabolism remain scarce. SUBJECTS: We studied a group of 37 obese premenopausal women (age: 24-52 y; mean BMI = 43.7 kg/m2) who underwent LAGB. METHODS: Serum calcium, phosphate, alkaline phosphatase, parathormone (PTH), vitamin D3, serum C-telopeptides, IGFBP-3 and IGF-1 were measured at baseline, 6, 12, 18 and 24 months after surgery. Body composition, bone mineral content (BMC) and density (BMD) were measured using dual-X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months after surgery. RESULTS: There was no clinically significant decrease of calcemia; PTH remained stable. Serum telopeptides increased by 100% (P < 0.001) and serum IGFBP-3 decreased by 16% (P < 0.001) during the first 6 months, and then stabilized, whereas IGF-1 remained stable over the 2 y. BMC and BMD decreased, especially at the femoral neck; this decrease was significantly correlated with the decrease of waist and hip circumference. CONCLUSIONS: We concluded that there was no evidence of secondary hyperparathyroidism 24 months after LAGB. The observed bone resorption could be linked to the decrease of IGFBP-3, although this decrease could be attributable to other confounding factors. Serum telopeptides seem to be a reliable marker of bone metabolism after gastric banding. DXA must be interpreted cautiously during major weight loss, because of the artefacts caused by the important variation of fat tissue after LAGB.
Mots-clé
Absorptiometry, Photon, Adult, Biological Markers, Bone Density, Bone Resorption, Collagen Type I, Female, Gastroplasty, Humans, Hyperparathyroidism, Secondary, Middle Aged, Obesity, Morbid, Peptides, Premenopause
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
20/08/2019 14:22
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