Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.

Détails

ID Serval
serval:BIB_34EABE463AEA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.
Périodique
Pulmonary pharmacology & therapeutics
Auteur⸱e⸱s
Vernooy J.H., Ubags N.D., Brusselle G.G., Tavernier J., Suratt B.T., Joos G.F., Wouters E.F., Bracke K.R.
ISSN
1522-9629 (Electronic)
ISSN-L
1094-5539
Statut éditorial
Publié
Date de publication
08/2013
Peer-reviewed
Oui
Volume
26
Numéro
4
Pages
464-472
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance between food intake and energy expenditure by signalling through its functional receptor (Ob-Rb) in the hypothalamus. Structurally, leptin belongs to the long-chain helical cytokine family, and is now known to have pleiotropic functions in both innate and adaptive immunity. The presence of the functional leptin receptor in the lung together with evidence of increased airspace leptin levels arising during pulmonary inflammation, suggests an important role for leptin in lung development, respiratory immune responses and eventually pathogenesis of inflammatory respiratory diseases. The purpose of this article is to review our current understanding of leptin and its functional role on the different resident cell types of the lung in health as well as in the context of three major respiratory conditions being chronic obstructive pulmonary disease (COPD), asthma, and pneumonia.
Mots-clé
Adaptive Immunity, Animals, Asthma/immunology, Asthma/physiopathology, Humans, Immunity, Innate, Inflammation/immunology, Inflammation/physiopathology, Leptin/immunology, Leptin/metabolism, Lung/immunology, Lung/physiology, Lung/physiopathology, Pneumonia/immunology, Pneumonia/physiopathology, Pulmonary Disease, Chronic Obstructive/immunology, Pulmonary Disease, Chronic Obstructive/physiopathology
Pubmed
Web of science
Création de la notice
29/04/2022 21:16
Dernière modification de la notice
30/04/2022 6:37
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